血管麻痹综合征的潜在治疗靶点:氧自由基  

Potential therapeutic targets on vasoplegic syndromes:oxygen free radicals

作　　者：俞莹[1] 黄巧文 翁险峰[1] 张良成[1] 彭勇刚[3] YU Ying;HUANG Qiaowen;WENG Xianfeng;ZHANG Liangcheng;PENG Yonggang(Department of Anesthesiology,Fujian Medical University Union Hospital,Fuzhou 350001;Department of Anesthesiology,Fujian Medical University Affiliated Zhangzhou Hospital,Zhangzhou 363000,China;Department of Anesthesiology,Shands Hospital of University of Florida,Florida 32610,USA)

机构地区：[1]福建医科大学附属协和医院麻醉科,福建福州350001 [2]福建医科大学附属漳州市医院麻醉科,福建漳州363000 [3]美国佛罗里达大学Shands医院麻醉科,美国佛罗里达州32610

出　　处：《麻醉安全与质控》2020年第6期321-326,共6页Perioperative Safety and Quality Assurance

摘　　要：血管麻痹综合征(VS)在心脏大手术和脓毒症休克中多见,主要特征是血管活性药物难以纠正的严重低血压、低外周血管阻力而心输出量正常或偏高。VS的机制复杂,其中氧自由基在病理条件下的增多是一个重要的病因,本文重点阐述了氧自由基在VS中的作用机制,并介绍了针对氧自由基治疗VS的现状。Vasoplegic syndromes(VS),as well observed in major cardiac surgeries and septic shock,are characterized by profound hypotension being refractory to vasopressor therapies,low systemic vascular resistance and normal or high cardiac output.Mechanism of VS is complex while increased oxygen free radicals under pathological conditions are considered to be major causes.Here we outline the possible mechanism of oxygen free radicals in VS and describe treatment options targeted on oxygen free radicals.

关 键 词：血管麻痹综合症 氧自由基 危险因素 

分 类 号：R543[医药卫生—心血管疾病]