纳米材料人工韧带骨连接及在抗粘连领域的研究与应用  

Research and application of bone connection and anti-adhesion of nanomaterial artificial ligaments

作　　者：严浩 齐志明[1] Yan Hao;Qi Zhiming(Department of Sports Medicine,Dalian Municipal Central Hospital,Dalian 116000,Liaoning Province,China)

机构地区：[1]大连市中心医院运动医学科,辽宁省大连市116000

出　　处：《中国组织工程研究》2021年第16期2605-2611,共7页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省自然科学基金项目(201800935),项目负责人:齐志明。

摘　　要：背景:纳米尺度的不规则结构模拟了自然细胞外基质分子中的结构,可作为细胞黏附或增殖的载体,促进植入部位的组织再生。目的:对纳米材料人工韧带应用于韧带重建的研究进展进行综述。方法:应用计算机检索中国知网、PubMed、Web of science、embase、维普资讯和万方数据库,检索词为"组织工程、纳米材料、人工韧带、Nanometre、Nanoscale、Artificial ligament"。根据标准纳入纳米材料人工韧带的研究进展的文献。结果与结论:纳米材料拥有良好的生物兼容性,经纳米材料修饰后的人工韧带可以为细胞提供良好的黏附环境,并且可以促进细胞增殖。骨髓间充质干细胞可以在纳米材料修饰过的人工韧带表面增殖分化,促进骨长入韧带,这种效应加强了韧带的强度且在一定程度上促进了腱骨愈合。纳米材料支架是一种很有前途的治疗韧带损伤的方案,目前的纳米纤维制备技术为这种方案的实施奠定了基础。目前的纳米纤维可以提供理想的力学强度,部分纳米材料具有可降解性,在植入后可以促进成纤维细胞增殖,逐步替代纳米纤维直至达到韧带再生。对纳米材料支架的研究在骨连接和抗粘连方面也取得了一定的进展。BACKGROUND:Irregular structures on the nanometer scale mimic the structure of natural extracellular matrix molecules,and can be used as a carrier for cell adhesion or proliferation to promote tissue regeneration at the site of implantation.OBJECTIVE:To review the research progress of nanomaterial artificial ligament applied in ligament reconstruction.METHODS:Computer was used to search CNKI,PubMed,Web of Science,Embase,Cqvip and Wanfang databases.The search terms were"tissue engineering,nanomaterials,artificial ligaments,nanometre,nanoscale,artificial ligament".According to the standard,the research progress of nanomaterial artificial ligament was included in the literature.RESULTS AND CONCLUSION:Nanomaterials have good biological compatibility.Artificial ligaments modified by nanomaterials can provide good adhesion environment for cells and promote cell proliferation.Bone marrow mesenchymal stem cells can proliferate and differentiate on the surface of artificial ligaments modified by nanomaterials and promote the extension of bone into ligaments.This effect enhances the strength of ligaments and promotes tendon and bone healing to a certain extent.Nanomaterial scaffold is a promising solution for the treatment of ligament injuries.The current nanofiber preparation technology has laid the foundation for the implementation of this solution.Currently,the prepared nanofibers can provide ideal mechanical strength,and some nanomaterials are degradable.After implantation,they can promote the proliferation of fibroblasts and gradually replace the nanofibers until ligament regeneration is achieved.The research of nanomaterial scaffold has also made some progress in bone connection and anti-adhesion.

关 键 词：材料 纳米材料 韧带 韧带损伤 人工韧带 组织工程 骨 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]