肺癌体素内不相干运动磁共振扩散加权成像的可行性及可重复性研究  

Feasibility and repeatability of intravoxel incoherent motion diffusion weighted imaging for lung cancer

作　　者：卢绍辉[1] 廖书坤 武飞 吴隆秋[2] 吴迪[1] 刘少强[1] LU Shao-hui;LIAO Shu-kun;WU Fei;WU Long-qiu;WU Di;LIU Shao-qiang(Department of Image Center,The First Affiliated Hospital of Gannan Medical University;Department of Oncology,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一附属医院影像科 [2]赣南医学院第一附属医院肿瘤内科,江西赣州341000

出　　处：《赣南医学院学报》2020年第9期944-947,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：2019年江西省卫生健康委员会科研课题(编号:20195412)。

摘　　要：目的:研究肺癌病灶体素内不相干运动磁共振扩散加权成像的可行性及可重复性。方法:使用飞利浦3.0T磁共振对62例肺癌患者进行前后2次体素内不相干运动磁共振扩散加权成像扫描。将肺癌分成肿块组、结节组及纵膈肿大淋巴结转移组,利用IMAgenGINE磁共振弥散后处理软件生成体素内不相干运动相关的参数图(D、D*、f)。结果:其中60例患者顺利完成扫描,58例患者图像质量达到评估要求。D值:不同测量者之间以及前后两次检查之间,肿块组、结节组和纵膈肿大淋巴结组的组内相关系数均可靠性高(大于0.90);f值:肿块组不同测量者及前后两次检查的组内相关系数可靠性较高(0.86)或中等(0.64),结节组不同测量者及前后两次检查的组内相关系数均可靠性较低(0.25、0.04),纵膈肿大淋巴结组不同测量者及前后两次检查的组内相关系数均可靠性较好(0.84、0.92);D*:不同测量者之间以及前后两次检查之间,肿块组、结节组和纵膈肿大淋巴结组的组内相关系数可靠性中等或较差(均小于0.75)。结论:肺癌体素内不相干运动磁共振扩散加权成像方法可行;D值的可重复性最好,纵膈肿大淋巴结组f值重复性好,肿块组f值重复性好于结节组;D*的重复性较差。Objective:To investigate the feasibility and repeatability of magnetic resonance diffusion-weighted intravoxel incoherent motion(DW-IVIM)imaging in lung cancer.Methods:Sixty-two lung cancer patients,which were divided into mass,nodule and mediastinal lymph node metastasis groups,underwent lung DW-IVIM examination twice on a 3.0Tesla Philips MR scanner.Parameter maps of D,D*and f were generated by using IMAgenGINE diffusion post-processing software.Results:Sixty patients performed the scan and the images of fifty-eight patients could be evaluated.D value,the intergroup correlation coefficients between different readers and twice examination of mass,nodules and mediastinal lymph node groups were all excellent(>0.90).F value of the mass group,with different readers and twice examinations,the correlation coefficients were reliable(0.86)or moderate(0.64),in the nodule group,the correlation coefficients were low(0.25,0.04),in the mediastinal lymph node group,the correlation coefficients were reliable(0.84,0.92).D*value,the intergroup correlation coefficients between different readers and twice examination of mass,nodules and mediastinal lymph node were moderate or poor(all were less than 0.75)with different readers and twice examination.Conclusion:The method of intravoxel incoherent motion diffusion weighted imaging for lung cancer is feasible.The repeatability of D value was the excellent.and the repeatability of f value of mediastinal lymph node was good,and mass group was better than that of nodule.D*has poor repeatability.

关 键 词：肺癌 磁共振成像 扩散 体素内不相干性运动 

分 类 号：R445.2[医药卫生—影像医学与核医学]