α-卤代腙与α-异氰酸酯反应合成4-腙基-2-异氰基丁酸酯类化合物  

The Reaction ofα-Halo Hydrazones andα-Isocyano Esters to Access 4-Hydrazineylidene-2-isocyanobutanoates

作　　者：全保学 赵建强 袁伟成[1] QUAN Bao-xue;ZHAO Jian-qiang;YUAN Wei-cheng(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;Institute for Advanced Study, Chengdu University, Chengdu 610106, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]成都大学高等研究院,四川成都6101062 [3]中国科学院大学,北京100049

出　　处：《合成化学》2020年第10期890-895,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21871252,21901024)。

摘　　要：α-卤代腙与α-异氰酸酯在三乙胺作用下反应,生成4-腙基-2-异氰基丁酸酯类化合物。通过优化合成工艺,确定最佳反应条件为:α-卤代腙(1.0 eq.),α-异氰酸酯(1.2 eq.),三乙胺(1.2 eq.),二氯甲烷作溶剂,反应24 h。在此条件下进行了底物普适性研究,以高达79%的收率得到一系列具有潜在价值的4-腙基-2-异氰基丁酸酯类化合物,产物结构经1H NMR,13C NMR和MS(ESI)确证。A series of 4-hydrazineylidene-2-isocyanobutanoates with potential values were obtained in up to 79%yield by the reactions ofα-isocyano esters withα-halo hydrazones.The optimal conditions were confirmed:α-halo hydrazones(1.0 eq.)andα-isocyano esters(1.2 eq.)in CH2Cl2 with Et3N(1.2 eq.)at room temperature for 24 h.The structures were confirmed by 1H NMR,13C NMR and MS(ESI).

关 键 词：α-异氰酸酯 α-卤代腙 三乙胺 工艺优化 合成 

分 类 号：O621.3[理学—有机化学]