2型糖尿病患者远端对称性多发性神经病变与肌肉质量减少的关系  

The relationship between distal symmetric polyneuropathy and muscle mass loss in type 2 diabetes mellitus

作　　者：张欣欣 孔悠然 王叙馥[2] 段明 董冰子 孙晓方[1] 王颜刚[1] 袁鹰[1] Zhang Xinxin;Kong Youran;Wang Xufu;Duan Ming;Dong Bingzi;Sun Xiaofang;Wang Yangang;Yuan Ying(Department of Endocrinology and Metabolism,the Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Nuclear Medicine,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院内分泌与代谢病科,266000 [2]青岛大学附属医院核医学科,266000

出　　处：《中华糖尿病杂志》2020年第9期716-720,共5页CHINESE JOURNAL OF DIABETES MELLITUS

摘　　要：目的探讨2型糖尿病患者远端对称性多发性神经病变(DSPN)与肌肉质量减少的关系。方法选取2019年1月至8月于青岛大学附属医院内分泌与代谢病科住院患者,纳入符合入组条件的2型糖尿病(T2DM)患者469例,根据亚洲肌少症工作组诊断标准将研究对象分为肌量减少组(169例)与非肌量减少组(300例),比较两组间各观察指标差异,根据中国2型糖尿病防治指南,将患者分为DSPN组(296例)和非DSPN组(173例),比较两组间肌量减少患病率,利用二分类logistic模型探索DSPN与肌量减少的相关性,组间比较采用Mann-Whitney U检验。结果纳入T2DM患者469例,肌量减少患者169例,DSPN组肌量减少患病率明显高于非DSPN组(40.88%比27.75%,χ²=8.17,P<0.05)。单因素Logistic回归结果示DSPN是T2DM患者肌量减少发生的危险因素(OR=1.786,95%CI 1.190~2.680,P=0.005),当校正年龄、体质指数等因素后,DSPN与肌量减少的相关性仍存在(OR=1.807,95%CI 1.162~2.809,P=0.009)。结论T2DM患者肌量减少在DSPN患者中更为常见,DSPN为T2DM患者肌量减少的危险因素。Objective To explore the relationship between distal symmetric polyneuropathy and muscle mass loss in patients with type 2 diabetes mellitus (T2DM).Methods The inpatients in the Department of Endocrinology and Metabolism of the Affiliated Hospital of Qingdao University from January to August 2019 were selected as subjects;469 patients with type 2 diabetes who met the enrollment criteria were included. According to the diagnostic criteria of the Asian Working Group for Sarcopenia (AWGS),the patients were divided into muscle mass loss group and non-muscle mass loss group (300 cases). The differences in the observed indicators between the two groups were compared;According to the guidelines for the prevention and treatment of type 2 diabetes in China,the patients were divided into DSPN group (296 cases) and non-DSPN group (173 cases), the prevalence of muscle mass loss between the two groups was compared,and the correlation between DSPN and muscle mass loss was explored using a binary logistic model,Mann-whitney U test was used for comparison between groups.Results A total of 469 patients with T2DM were included,including 169 patients with muscle mass loss. The prevalence of muscle mass loss in the DSPN group was significantly higher than that in the non-DSPN group (40.88%vs27.75%, P<0.05). Univariate logistic regression results showed that DSPN was a risk factor for muscle mass loss in T2DM patients (OR=1.786, 95%CI 1.190-2.680, P=0.005). After adjusting for age, BMI and other factors,the correlation between DSPN and muscle mass loss still exists (OR=1.807, 95%CI 1.162-2.809, P=0.009).Conclusion Muscle mass loss is more common in DSPN patients with T2DM, which is a risk factor for muscle mass loss.

关 键 词：糖尿病 2型 远端对称性多发性神经病变 肌量减少 肌少症 

分 类 号：R587.2[医药卫生—内分泌] R685[医药卫生—内科学]