乙型肝炎病毒感染的实验室诊断:现在与未来  

Laboratory diagnosis of HBV infection: present and future

作　　者：傅亚[1] 刘灿[1] 欧启水[1] Fu Ya;Liu Can;Ou Qishui(Department of Laboratory Medicine,the First Affiliated Hospital,First Clinical College of Fujian Medical University,Fujian Key Laboratory of Laboratory Medicine,Institute of Genetic Diagnosis of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院,福建医科大学第一临床医学院检验科,福建省检验医学重点实验室,福建医科大学基因诊断研究室,福州350005

出　　处：《中华检验医学杂志》2020年第9期849-854,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81572067、81971996、81672101)。

摘　　要：我国目前乙型肝炎病毒(HBV)感染的防治工作形势依然严峻。影响HBV感染的进程和结局的因素主要包括病毒和宿主两个方面。在不断挖掘HBV感染经典诊断指标如乙型肝炎表面抗原、乙型肝炎核心抗体、乙型肝炎病毒DNA等新的临床意义的同时,更要关注新的指标如乙型肝炎病毒RNA、乙型肝炎核心相关抗原等的应用价值与前景。随着组学概念的提出与技术的发展,人们开始以组学的理念关注HBV感染,并整合基因组学、代谢组学、蛋白组学等,以达到精准诊断的目标。At present,the situation of prevention and treatment of hepatitis B(HBV)infection in China is still serious.Factors affecting the course and outcome of HBV infection mainly include virus and hosts.While exploring the new clinical significance of HBV infection classic diagnostic indicators such as hepatitis B sunface antigen,hepatitis B core antibody and HBV DNA,more attention should be paid to the application value and prospect of new indicators such as HBV RNA and hepatitis B core-related antigen.With the proposing of the omics concept and the development of technology,people begin to focus on HBV infection with the concept of omics and integrate genomics,metabolomics,proteomics,etc.,to achieve the goal of accurate diagnosis.

关 键 词：乙型肝炎病毒 乙型肝炎 临床实验室技术 乙型肝炎表面抗原 乙型肝炎核心抗原 基因组学 代谢组学 

分 类 号：R512.62[医药卫生—内科学] R446.6[医药卫生—临床医学]