血清淀粉样蛋白A在新型冠状病毒肺炎诊疗中的应用价值  

The clinical application of serum amyloid A in the diagnosis and treatment of COVID-19

作　　者：顾敏晔 顾国浩[2] 石亚玲[3] 胡晓波[4] 范久波[5] 徐莹 徐建新 Gu Minye;Gu Guohao;Shi Yaling;Hu Xiaobo;Fan Jiubo;Xu Ying;Xu Jianxin(Shanghai iPOCT Medical Engineering Research Center,Shanghai 201201,China;Department of Clinical Laboratory,The First Affiliated Hospital of SOOCHOW University,Suzhou 215000,China;Department of Clinical Laboratory,Guangzhou Eighth People′s Hospital,Guangzhou 510000,China;Department of Clinical Laboratory,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200003,China;Department of Clinical Laboratory,Xiangyang Central Hospital,Xiangyang 441000,China;Department of Clinical Laboratory,Ningbo Women&Children′s Hospital,Ningbo 315000,China)

机构地区：[1]上海即时检测医学工程技术研究中心,上海201201 [2]苏州大学附属第一医院检验科,苏州215000 [3]广州市第八人民医院检验科,广州510000 [4]上海中医药大学附属龙华医院检验科,上海200003 [5]襄阳市中心医院湖北文理学院附属医院医学检验部,襄阳441000 [6]浙江省宁波市妇女儿童医院检验科,宁波315000

出　　处：《中华检验医学杂志》2020年第9期935-938,共4页Chinese Journal of Laboratory Medicine

基　　金：上海市科学技术委员会科研计划项目 (18DZ2250700、17DZ1930300)。

摘　　要：血清淀粉样蛋白A(SAA)是急性感染,尤其是病毒感染时的新标志物。新型冠状病毒肺炎(COVID-19)疫情中,SAA在早期辅助诊断、感染轻重分型、病程进展及转归评估等方面均体现了一定作用。本文介绍SAA结构功能、动态监测在COVID-19辅助诊断和病程中的应用,及与新型冠状病毒抗体、核酸及其他辅助诊断指标联合检测意义。Serum amyloid A(SAA)is a novel marker widely used in the acute infection disease,especially viral infection.SAA has shown a cerntain value in assisting the clinical diagnosis,discrimination of severity and monitoring of progress and outcome of COVID-19.This paper introduces the application of SAA structural,function andits dynamic detection in the diagnosis of COVID-19,and the significance of combined detection with COVID-19 antibodies,nucleic acid and other diagnostic indicators.

关 键 词：新型冠状病毒肺炎 严重急性呼吸综合征冠状病毒2型 血清淀粉样蛋白A 急相蛋白质类 

分 类 号：R563.1[医药卫生—呼吸系统] R446.1[医药卫生—内科学]