胎膜TRAIL表达水平及血液相关炎性标志物水平在胎膜早破发生中的作用与关系  

The role and relationship between the expression level of TRAIL of fetal membranes and the level of blood-related inflammatory markers in the occurrence of premature rupture of membranes

作　　者：吴兆晴 杨玉姣[2] 李晓琼[2] 周文丽[2] 张曙萱 WU Zhaoqing;YANG Yujiao;LI Xiaoqiong;ZHOU Wenli;ZHANG Shuxuan(Department of Obstetrics,Xuzhou Medical University,Huai′an Maternal and Child Health Care Hospital of Jiangsu Province,Jiangsu Province,Huai′an223002,China;Department of Obstetrics,Huai′an Maternal and Child Health Care Hospital of Jiangsu Province,Jiangsu Province,Huai′an223002,China;Department of Obstetrics,Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University,Jiangsu Province,Xuzhou221006,China)

机构地区：[1]徐州医科大学江苏省淮安市妇幼保健院产科,江苏淮安223002 [2]江苏省淮安市妇幼保健院产科,江苏淮安223002 [3]徐州医科大学附属徐州市立医院产科,江苏徐州221006

出　　处：《中国医药导报》2020年第30期24-27,共4页China Medical Herald

基　　金：江苏省妇幼健康科研项目(F201731)。

摘　　要：目的探讨胎膜中肿瘤坏死因子相关凋亡配体(TRAIL)水平与血清炎性标志物水平在胎膜早破发病机制中的作用及关系。方法选取2019年1—12月江苏省淮安市妇幼保健院收住的80例胎膜早破产妇为研究对象,根据破膜孕龄将其分为足月胎膜早破组(孕龄≥37周,46例)、早产胎膜早破组(孕龄28~36+6周,34例)。选取同期80名足月胎膜完整产妇作为对照组。检测三组胎膜组织中TRAIL及血液中相关炎性标志物水平[中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)及淋巴细胞单核细胞比值(LMR)]并分析胎膜组织中TRAIL与炎性标志物水平相关性。结果早产胎膜早破组TRAIL阳性率,TRAIL mRNA表达水平,血清NLR、PLR、LMR水平高于足月胎膜早破组及对照组(均P<0.05);足月胎膜早破组TRAIL阳性率,TRAIL mRNA表达水平,血清NLR、PLR、LMR水平高于对照组(均P<0.05)。胎膜组织中TRAIL表达水平与血清NLR、PLR、LMR水平呈正相关(r=0.543、0.574、0.651,均P<0.05)。结论TRAIL及血清相关炎性标志物在胎膜早破产妇胎膜中高表达,二者存在正相关。Objective To explore the role and relationship between the expression level of tumor necrosis factor-related apoptotic ligand(TRAIL)of membranes and serum inflammatory markers level in the pathogenesis of premature rupture of membranes.Methods From January to December 2019,80 cases of premature rupture of membranes pregnant women admitted to Huai′an Maternal and Child Health Care Hospital of Jiangsu Province were selected as the research objects.They were divided into full-term premature rupture of membranes group(gestational age≥37 weeks,46 cases)and preterm premature rupture of membranes group(gestational age 28-36+6 weeks,34 cases).80 pregnant women of full-term fetal membranes were selected as control group in the same period.TRAIL in membranes tissue and blood related inflammatory markers(neutrophil lymphocyte ratio[NLR],platelet lymphocyte ratio[PLR]and lymphocyte monocyte ratio[LMR])were measured and the correlation between TRAIL and inflammatory markers in membranes tissue was analyzed.Results The TRAIL positive rate,TRAIL mRNA expression level and serum NLR,PLR,LMR levels in preterm premature rupture of membranes group were higher than those of full-term premature rupture of membranes group and control group(all P<0.05),and the TRAIL positive rate,TRAIL mRNA expression level and serum NLR,PLR,LMR levels in full-term premature rupture of membranes group were higher than those of control group(all P<0.05).TRAIL expression level in fetal membranes was positively correlated with serum NLR,PLR and LMR levels(r=0.543,0.574,0.651,all P<0.05).Conclusion TRAIL and serum-related inflammatory markers are highly expressed in the membranes of women with premature rupture of foetal membranes,and there is a positive correlation between them.

关 键 词：胎膜早破 肿瘤坏死因子相关凋亡配体 中性粒细胞淋巴细胞比值 血小板淋巴细胞比值 

分 类 号：R714.433[医药卫生—妇产科学]