中医药干预慢性阻塞性肺疾病相关信号通路传导的研究进展  

Research progress of traditional Chinese medicine intervention on signaling pathway transduction associated with chronic obstructive pulmonary disease

作　　者：封继宏[1] 张珊珊 毕明达 FENG Jihong;ZHANG Shanshan;BI Mingda(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin300150,China;Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin300193,China)

机构地区：[1]天津中医药大学第二附属医院呼吸与危重症医学科,天津300150 [2]天津中医药大学研究生院,天津300193

出　　处：《中国医药导报》2020年第30期37-40,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81673747)。

摘　　要：信号通路是一系列酶促反应通路,它能将胞外的激素、生长因子、神经递质等分子信号通过细胞膜传至细胞内发挥效应。慢性阻塞性肺疾病作为一种发病率和致残率都很高的疾病,其成因复杂,多种信号通路在其发生、发展的过程中都具有重要作用。中医药可通过干预多种信号通路来改善慢性阻塞性肺疾病患者的病情。本文对近几年相关文献进行系统梳理,整理出JAK/STAT、PPARs、MAPK、TGF-β1/Smads、PI3K/AKT、TLR4/NF-κB及Keap1-Nrf2-ARE等7条信号通路,希望对中医药治疗慢性阻塞性肺疾病的药物研究提供一定的参考。The signaling pathway is a series of enzymatic reaction pathway,which can transmit extracellular hormone,growth factor,neurotransmitter and other molecular signals through the cell membrane to the intracellular effect.As a disease with high morbidity and disability rate,chronic obstructive pulmonary disease has complex causes,and various signaling pathways play an important role in its development.Traditional Chinese medicine can improve the condition of chronic obstructive pulmonary disease patients by intervening in a variety of signaling pathways.In this paper,the related literature in recent years is systematically sorted out,and seven signaling pathways including JAK/STAT,PPARs,MAPK,TGF-β1/Smads,PI3K/AKT,TLR4/NF-κB and Keap1-Nrf2-ARE are sorted out.It is hoped to provide some reference for the research of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease.

关 键 词：中药 慢性阻塞性肺疾病 信号通路 研究进展 

分 类 号：R563[医药卫生—呼吸系统]