艾灸联合缬沙坦治疗早期糖尿病肾病的临床效果  

Clinical efficacy of moxibustion combined Valsartan in the treatment of early diabetic nephropathy

作　　者：黄海[1,2] 郭逸[2,3] 陈丽 金劲松[2,5] HUANG Hai;GUO Yi;CHEN Li;JIN Jingsong(Department of Massage Rehabilitation,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan430074,China;Hubei Academy of Traditional Chinese Meicine,Hubei Province,Wuhan430074,China;Department of Endocrinology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan430074,China;College of Acupuncture and Orthopedics,Hubei University of Chinese Meicine,Hubei Province,Wuhan430061,China;Department of Nephrology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan430074,China)

机构地区：[1]湖北省中医院推拿康复科,湖北武汉430074 [2]湖北省中医药研究院,湖北武汉430074 [3]湖北省中医院内分泌科,湖北武汉430074 [4]湖北中医药大学针灸骨伤学院,湖北武汉430061 [5]湖北省中医院肾病科,湖北武汉430074

出　　处：《中国医药导报》2020年第30期76-79,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81804170);湖北省卫生健康委员会中医药科研立项项目(ZY2019M046)。

摘　　要：目的观察艾灸联合缬沙坦对早期糖尿病肾病(DN)的临床效果。方法选取2018年8月—2019年10月湖北省中医院肾病科门诊诊治的48例早期DN患者为研究对象。依据随机数表法将其分为对照组和观察组,每组24例。对照组在基础治疗上给予缬沙坦,观察组在对照组基础上加用艾灸治疗,共治疗4周。比较两组治疗前后24 h尿量(24 h-UV)、24 h尿蛋白(24 h-UP)、尿微量白蛋白(MAU)、尿转铁蛋白(TRF)、尿α1微球蛋白(α1-MG)、尿视黄醇结合蛋白(RBP)、血尿素氮(BUN)、血肌酐(Scr)水平。结果治疗后,两组24 h-UV、24 h-UP、MAU、TRF、α1-MG、RBP、BUN、Scr水平低于治疗前(均P<0.05)。治疗后,观察组24 h-UV、24 h-UP、MAU、α1-MG、RBP水平低于对照组(均P<0.05);两组BUN、Scr、TRF水平比较,差异无统计学意义(P>0.05)。结论艾灸联合缬沙坦治疗能够有效降低早期DN患者尿微量蛋白排泄,减轻肾脏损伤,值得临床应用和研究。Objective To observe the clinical efficacy of moxibustion combined Valsartan in the treatment of early diabetic nephropathy(DN).Methods From August 2018 to October 2019,48 patients with early DN who diagnosed and treated in Department of Nephrology,Hubei Provincial Hospital of Traditional Chinese Medicine were selected as the study subjects.They were divided into the control group and the observation group according to the random table number method,with 24 cases in each group.The control group was given Valsartan on the basis of basic treatment,and the observation group was treated with moxibustion on the basis of the control group.Four weeks for treatment.The urine volume during 24 hours(24 h-UV),urine protein during 24 hours(24 h-UP),microalbuminuria(MAU),urinary transferrin(TRF),urinaryα1 microglobulin(α1-MG),urinary retinol-binding protein(RBP),blood urea nitrogen(BUN),serum creatinine(Scr)levels were compared before and after treatment between two groups.Results After treatment,24 h-UV,24 h-UP,MAU,TRF,α1-MG,RBP,BUN and Scr levels in two groups were lower than those before treatment(all P<0.05).24 h-UV,24 h-UP,MAU,α1-MG and RBP levels in the observation group were lower than those in the control group(all P<0.05);but there were no statistically significant differences in BUN,Scr and TRF levels(P>0.05).Conclusion Moxibustion combined Valsartan can effectively reduce the excretion of urinary microprotein during early DN and alleviate renal kidney damage,so it is worthy of clinical application and research.

关 键 词：艾灸 缬沙坦 早期糖尿病肾病 尿微量蛋白 肾功能 

分 类 号：R587.2[医药卫生—内分泌]