噻嗪酮合成的清洁化  

Clean Manufacturing Process for Synthesis of Buprofezin

作　　者：王同涛[1] 孙绪兵[1] 李和娟 杨明生[1] 陈永平[1] 裴利娟 李振兴[1] Wang Tongtao;Sun Xubing;Li Hejuan;Yang Mingsheng;Chen Yongping;Pei Lijuan;Li Zhenxing(Shandong Huayang pesticide chemical group Co.,Ltd,Taian Shandong 271411,China)

机构地区：[1]山东华阳农药化工集团有限公司,山东泰安271411

出　　处：《农药科学与管理》2020年第10期29-34,共6页Pesticide Science and Administration

摘　　要：以N-甲基苯胺、光气为原料酰化合成N-甲基-N-苯基氨基甲酰氯,再和氯气反应,氯化合成N-氯甲基-N-苯基氨基甲酰氯,它与丁丙硫脲缩合生成噻嗪酮,含量98%以上,以N-甲基苯胺计,总收率78.6%。该工艺反应条件温和,工艺清洁,产品质量好,收率高,生产成本低,适合于工业化生产。N-methyl-n-phenyl carbamoyl chloride,synthesized by acylation of n-methylaniline and phosgene,reacted with chlorine gas to produce n-chloromethyl-n-phenyl carbamoyl chloride.The total yield was 78.6%.The process is clean,high-quality,with high yield rate and low production cost under mild reaction conditions,which is suitable for industrial-scale production.

关 键 词：噻嗪酮 N-甲基苯胺 光气 丁丙硫脲 

分 类 号：S482.3[农业科学—农药学]