Preparation and characterization of zinc oxide nanoparticles  

氧化锌纳米粒的制备与表征

作　　者：Man Liu Shuang Zhang Zhuoyue Li Guangxue Wang Jingru Wang Xuan Zhang 刘曼;张爽;李卓越;王光雪;王景茹;张烜(北京大学医学部药学院,分子药剂学与新释药系统北京市重点实验室,北京100191;北京大学医学部药学院药剂学系,北京100191)

机构地区：[1]Beijing Key Laboratory1 of Molecular Pharmaceutics and New Drug Delivery Systems,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China [2]Department of Pharmaceutics,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2020年第9期617-625,共9页中国药学（英文版）

基　　金：National Natural Science Foundation of China(Grant No.81773646);the National Key Research and Development Program of China(Grant No.2017YFA0205600);the Innovation Team of the Ministry of Education(Grant No.BMU2017TD003)。

摘　　要：In the present study, the zinc oxide nanoparticles(ZnO NPs) were prepared by using a sol-gel method. The characterization of ZnO NPs, such as particle size, morphology, crystal form, optical properties and p H-responsive behavior, was carried out. The in vitro anti-tumor activity of ZnO NPs was evaluated on PC-3M and 4T1 cell lines. The results indicated that ZnO NPs were spherical NPs with uniform particle size, excellent fluorescence properties, and p H-responsive behavior. The in vitro anti-tumor activity of ZnO NPs was observed on PC-3M and 4T1 cell lines. Considering to above characteristics, Zn O NPs could be used as drug delivery carries for loading active compound performing therapeutic and diagnostic effect.本研究采用溶胶-凝胶法制备氧化锌纳米粒(ZnO NPs),并对其粒径、形貌、晶型、光学特性和pH敏感性等理化性质进行表征,在PC-3M和4T1两株细胞系上对ZnO NPs的体外抗肿瘤药效进行评价。实验结果表明,ZnO NPs为粒径均匀的球形纳米颗粒,具有优良的光学性能及pH敏感性能,对PC-3M和4T1两株细胞系有明显的抗肿瘤细胞药效。上述结果表明, ZnO NPs可作为载体载带活性物质以产生抗肿瘤诊断和治疗作用。

关 键 词：Zinc oxide nanoparticles Sol-gel method Size and morphology Optical properties In vitro anti-tumor activity 

分 类 号：R944[医药卫生—药剂学]