石家庄地区45例COVID-19患者临床特征分析  

Analysis of clinical characteristics of 45 COVID-19 patients in Shijiazhuang

作　　者：王德华[1] 郑欢伟[4] 王建民[1] 封丽琴[3] 卢伟娜[2] 董金红[1] 戴二黑[4] WANG De-hua;ZHENG Huan-wei;WANG Jian-min;FENG Li-qin;LU Wei-na;DONG Jin-hong;DAI Er-hei(Department of Interventional Medicine,the Fifth Hospital of Shijiazhuang,050021,China)

机构地区：[1]石家庄市第五医院介入医学科,050021 [2]石家庄市第五医院肝病科,050021 [3]石家庄市第五医院重症监护室,050021 [4]石家庄市第五医院肝病研究所,050021

出　　处：《传染病信息》2020年第5期416-418,425,共4页Infectious Disease Information

基　　金：石家庄市新型冠状病毒肺炎防控应急科研攻关项目(201460513A-3)。

摘　　要：目的分析石家庄地区45例新型冠状病毒肺炎(coronavirus diseases-2019,COVID-19)患者的流行病学特征、临床表现、治疗及预后情况,为COVID-19的防治提供参考。方法收集2020年1月21日—5月31日在石家庄市第五医院就诊的45例COVID-19患者临床信息,根据临床表现将患者分为无症状/轻型组,普通型组,重/危重型组,对比分析不同组间临床症状、实验室与影像学检查、治疗及预后情况。结果45例患者中,聚集性感染病例占57.78%;临床症状以发热、咳嗽/咳痰为主,重/危重型组患者发热比例更高;此外,患者年龄方面,重/危重型组明显高于其他2组(P<0.05);部分患者出现WBC、淋巴细胞计数下降,CRP升高及肝功能异常。其中3组之间淋巴细胞计数比较差异有统计学意义,两两比较,重/危重型组患者淋巴细胞计数显著低于无症状/轻型组(P<0.05)。3组之间CRP比较差异亦有统计学意义,两两比较,差异均有统计学意义(P均<0.05)。肺CT病变主要以双肺多发为主,多表现为磨玻璃样渗出。出院患者2周后复查核酸,7例患者核酸检测阳性。结论石家庄地区COVID-19患者临床特征与其他地区相似,但病例以聚集性为主,当地COVID-19疫情防控工作须持续加强,同时应重点强化中老年患者的防护与救治,并注意出院患者的随访观察。Objective To analyze the epidemiological characteristics,clinical manifestations,treatment and prognosis of 45 patients with coronavirus diseases-2019(COVID-19)in Shijiazhuang region,and to provide reference for COVID-19 prevention and treatment.Methods The clinical data of 45 COVID-19 patients in the Fifth Hospital of Shijiazhuang from January 21 to May 31,2020 were collected.According to the clinical manifestations,the enrolled patients were divided into asymptomatic/mild group,common group and severe/critical group.The clinical symptoms,laboratory and imaging examination,treatment and prognosis of different groups were compared and analyzed.Results Among the 45 patients,57.78%cases had cluster infection.The main clinical symptoms were fever and cough/expectoration.The incidence of fever was higher in the severe/critical group.In addition,the age of patients in the severe/critical group was significantly higher than that in the other 2 groups(P<0.05).Some patients had decreased WBC and lymphocyte count,increased CRP and abnormal liver function.Lymphocyte count showed statistically significant differences in 3 groups.By multiple comparison,the lymphocyte count in the severe/critical group was significantly lower than that in asymptomatic/mild group(P<0.05).CRP also showed statistically significant differences in 3 groups.By multiple comparison,the difference was statistically significance(P<0.05).Multiple lung CT lesions were prevalent in both lungs,represented by ground glass exudation.All patients were rechecked for nucleic acid at 2 weeks after discharge and 7 patients were tested positive for nucleic acid.Conclusions The clinical characteristics of COVID-19 patients in Shijiazhuang region are similar to those in other regions,but the affected cases are mainly clustered.Local COVID-19 epidemic prevention and control work should continue to be strengthened and focus on the protection and treatment of middle-aged and elderly patients,and monitor follow-up observations of discharged patients.

关 键 词：新型冠状病毒肺炎 流行病学 临床特征 氨溴索 预后 

分 类 号：R563.19[医药卫生—呼吸系统] R181.32[医药卫生—内科学]