沙美特罗替卡松粉吸入剂联合甲氧那明在慢性阻塞性肺疾病急性发作患者中的应用效果  

Application effect of Salmeterol and Fluticasone Powder Inhalant combined with Methoxyphenamine on acute exacerbation of chronic obstructive pulmonary disease

作　　者：杜树微 DU Shu-wei(Department of Respiratory Medicine,Shenyang First People′s Hospital,Liaoning Province,Shenyang110041,China)

机构地区：[1]沈阳市第一人民医院呼吸内科,辽宁沈阳110041

出　　处：《中国当代医药》2020年第30期64-66,70,共4页China Modern Medicine

摘　　要：目的探讨沙美特罗替卡松粉吸入剂联合甲氧那明在慢性阻塞性肺疾病(COPD)急性发作患者中的应用效果。方法选择2018年2月~2020年2月我院收治的80例COPD急性发作患者为研究对象,按照随机数字表法分为两组,每组各40例。对照组给予甲氧那明胶囊,观察组联合使用沙美特罗替卡松粉喷剂,比较两组的临床治疗情况中呼吸机治疗时间、总住院时间;比较两组治疗后1周肺功能指标情况;比较治疗中两组的圣·乔治医院呼吸问题调查问卷(SGRQ)评分;统计两组治疗期出现的并发症发生情况。结果观察组的使用呼吸机治疗时间、总住院时间短于对照组(P<0.05),治疗后1周观察组的肺功能指标中第1秒用力呼气容积(FEV1)和用力肺活量比值(FEV1/FVC)水平高于对照组(P<0.05),治疗后3 d和1周后,观察组的SGRQ评分高于对照组(P<0.05),观察组的SGRQ评分高于治疗前(P<0.05),观察组的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论对COPD急性发作患者使用沙美特罗替卡松喷剂,可有效缩短患者呼吸支持时间和住院时间,改善肺功能,提高呼吸质量,且并发症少,安全性高。Objective To investigate the application effect of Salmeterol and Fluticasone Powder Inhalant combined with Methoxyphenamine on acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 80 cases with acute exacerbation of COPD admitted to our hospital from February 2018 to February 2020 were selected and divided into two group according to random number table method,40 cases in each group.The control group was given Methoxyphenamine Capsules,the observation group was combined with Salmeterol and Fluticasone Powder Inhalant.Then the changes of ventilator treatment time,total hospitalization time in the two groups were compared.The changes of pulmonary function indexes in the two groups were compared 1 week after treatment.The St.George′s hospital respiratory questionnaire(SGRQ)scores in the two groups were compared.The complications which occurred during the treatment of the two groups were counted.Results The treatment time and total hospitalization time in the observation group were shorter than those in control group(P<0.05),1 week after intervention,the forced expiratory volume in one second(FEV1)and FEV1/forced vital capacity(FVC)levels in the lung function indexes in the observation group were higher than those of the control group(P<0.05),1 week after treatment,the SGRQ score in the observation group was higher than that of the control group(P<0.05),the SGRQ score in the observation group was higher than that before treatment(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Salmeterol and Fluticasone Spray for patients with acute exacerbation of COPD can effectively shorten the respiratory support time and hospitalization time of patients,so it can improve lung function and respiratory quality,and it has few complications and high safety.

关 键 词：沙美特罗替卡松喷剂 慢性阻塞性肺疾病 急性发作 甲氧那明 

分 类 号：R563[医药卫生—呼吸系统]