男性因素宫腔内人工授精临床妊娠率的独立危险因素分析  

Analysis of independent risk factors for clinical pregnancy rate of intra-uterine insemination with male factors

作　　者：林丽娜[1] 张哲欢[1] 周欣业 黄晓帆[1] 潘婷[1] LIN Li-na;ZHANG Zhe-huan;ZHOU Xin-ye;HUANG Xiao-fan;PAN Ting(Reproductive Medicine Center,Shantou Central Hospital,Guangdong Province,Shantou515075,China)

机构地区：[1]广东省汕头市中心医院生殖医学中心,广东汕头515075

出　　处：《中国当代医药》2020年第30期67-70,共4页China Modern Medicine

基　　金：广东省医学科学技术研究基金项目(A2015608)。

摘　　要：目的分析男性因素宫腔内人工授精(IUI)临床妊娠率的独立危险因素。方法回顾性分析2013年1月~2018年10月广东省汕头市中心医院收治的966个周期IUI患者的临床资料,探讨女方年龄、男方年龄、不孕年限、促排方案、不孕类型、IUI周期数、处理后前向精子总数等因素与IUI妊娠率的关系。结果单因素分析结果显示,女方年龄、男方年龄、促排方案、不孕类型、IUI周期数对男性因素IUI妊娠率的影响比较,差异无统计学意义(P>0.05)。不孕年限≤3年的妊娠率高于不孕年限>3年,处理后前向精子总数>107的妊娠率高于处理后前向精子总数≤107,差异有统计学意义(P<0.05)。Logistic多因素分析结果显示,不孕年限≤3年(β=0.459,OR=1.582,95%CI=1.055~2.372)及处理后前向精子总数>107(β=0.671,OR=1.114,95%CI=0.289~1.385)为影响男性因素IUI妊娠率的主要因素(P<0.05)。结论在男性因素IUI中,不孕年限及处理后前向精子总数均是影响临床妊娠率的独立危险因素;而女方年龄、男方年龄、促排方案、不孕类型、IUI周期数则无显著影响作用。Objective To analyze the independent risk factors for clinical pregnancy rate of intra-uterine insemination(IUI)with male factors.Methods Clinical data of 966 cycles of IUI patients who were admitted to Shantou Central Hospital in Guangdong Province from January 2013 to October 2018 were retrospectively analyzed.The relationship between IUI pregnancy rate and factors such as the age of the female,the age of the male,infertility duration,infertility program,type of infertility,number of IUI cycles,total number of forward sperm after treatment was investigated.Results The single-factor analysis results indicated that there were no statistically significant differences in the pregnancy rates among the age of the female,the age of the male,infertility program,type of infertility and the number of IUI cycles(P>0.05).The pregnancy rate of infertility duration≤3 years was higher than infertility duration>3 years,and the difference was statistically significant(P<0.05).The pregnancy rate of the total number of forward sperm after treatment>107 was higher than the total number of forward sperm after treatment≤107,and the difference was statistically significant(P<0.05).The multiple-factor analysis results indicated that the infertility duration≤3 years(β=0.459,OR=1.582,95%CI=1.055-2.372)and the total number of forward sperm after treatment>107(β=0.671,OR=1.114,95%CI=0.289-1.385)were risk factors of IUI clinical pregnancy rate(P<0.05).Conclusion The infertility duration and the total number of forward sperm after treatment are independent risk factors for the clinical pregnancy rate,while the age of the female,the age of the male,infertility program,the type of infertility and the number of IUI cycles have no significant effect.

关 键 词：宫腔内人工授精 妊娠率 影响因素 不孕年限 处理后前向精子总数 

分 类 号：R714.8[医药卫生—妇产科学]