血清Th1/Th2型细胞因子、PCT、CRP联合检测在老年社区获得性肺炎辅助诊断中的价值  

The diagnostic role of Th1/Th2 cytokines,PCT and CRP in community-acquired pneumonia in the elderly

作　　者：吴洁[1] 彭扬洋 朱功民 邱樊[1] WU Jie;PENG Yangyang;ZHU Gongmin;QIU Fan(Department of Nuclear Medicine,Nanjing Hospital Affiliated to Nanjing Medical University/Nanjing First Hospital,Nanjing,Jiangsu 210006,China)

机构地区：[1]南京医科大学附属南京医院/南京市第一医院核医学科,江苏南京210006

出　　处：《国际检验医学杂志》2020年第21期2566-2569,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(11805104)。

摘　　要：目的探讨Th1/Th2型细胞因子、降钙素原(PCT)、C反应蛋白(CRP)联合检测在老年社区获得性肺炎(CAP)早期辅助诊断中的价值。方法选取南京市第一医院2018年3月至2019年2月收治的老年CAP患者226例作为CAP组,60例体检健康者作为对照组。所有研究对象均采用流式细胞法定量检测血清中Th1/Th2型细胞因子,采用电化学发光法检测PCT,免疫比浊法检测CRP。结果CAP组CRP、白细胞介素(IL)-10、IL-6、IL-4水平较对照组均明显升高,差异均有统计学意义(P<0.05)。预测老年CAP,CRP灵敏度最高,PCT特异度最高。CRP与IL-6联合检测预测老年CAP价值最高,受试者工作特征曲线下面积为0.961,灵敏度为92.20%,特异度为90.50%。结论Th1/Th2型细胞因子、PCT、CRP联合检测可用于老年CAP的早期辅助诊断。Objective To assess the role of Th1/Th2 cytokines,procaltinin(PCT)and C reactive protein(CRP)in early diagnosis of community-acquired pneumonia(CAP)in the elderly.Methods A total of 226 cases of elder CAP admitted in Nanjing First Hospital from March 2018 to February 2019 were taken as CAP group and 60 cases of healthy persons were taken as control group.Flow cytometry was used to quantify the level of Th1/Th2 cytokines,electrochemiluminescence was used to quantify PCT level,and immunoturbidimetric assay was used to determine CRP level.Results PCT,CRP,interleukin(IL)-10,IL-6 and IL-4 were obviously increased in CAP group compared to control group,and the differences were statistically significant(P<0.05).CRP had the highest sensitivity in predicting CAP in elderly and PCT had the highest specificity.Combination of IL-6 and CRP had the best predictive value and the area under curve was 0.961,sensitivity was 92.20%and specificity was 90.50%.Conclusion Combination of Th1/Th2 cytokines,PCT and CRP could be helpful for early diagnosis of CAP in elderly.

关 键 词：老年社区获得性肺炎 TH1/TH2型细胞因子 降钙素原 C反应蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]