脑出血患者血清中TSP1/2、AQP4水平与病情及预后的关系  

Relationship between serum TSP1/2,AQP4 levels and condition,prognosis in patients with cerebral hemorrhage

作　　者：黄智伟 黄金武 HUANG Zhiwei;HUANG Jinwu(Department of Neurology,Putian Medical District of the 900th Hospital of the Joint Service Support Force of PLA,Putian,Fujian 351100,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇〇医院莆田医疗区神经内科,福建莆田351100

出　　处：《国际检验医学杂志》2020年第21期2660-2662,2667,共4页International Journal of Laboratory Medicine

摘　　要：目的分析脑出血患者血清中血小板反应蛋白(TSP)1、TSP2、水通道蛋白(AQP)4水平与病情及预后的关系。方法选取2016年1月至2020年1月收治的100例脑出血患者作为观察组,100例体检健康者作为健康对照组,100例脑梗死患者作为疾病对照组。检测所有研究对象血清TSP1、TSP2、AQP4水平;采用Logistics回归模型分析TSP1、TSP2及AQP4水平与患者病情及预后的关系。结果观察组血清TSP1、TSP2、AQP4水平均明显高于健康对照组和疾病对照组,差异均有统计学意义(P<0.05);不同严重程度脑出血患者血清中TSP1、TSP2、AQP4水平存在明显差异,其中重度组各项指标水平最高,轻度组最低,且差异均有统计学意义(P<0.05);预后质量良好组血清TSP1、TSP2、AQP4水平明显低于预后质量较差组,差异有统计学意义(P<0.05);脑出血患者血清中TSP1、TSP2、AQP4水平均为影响脑出血患者病情严重程度及预后质量的独立影响因素(P<0.05)。结论脑出血患者血清中TSP1、TSP2、AQP4水平异常升高,且各项指标是影响患者病情严重程度及预后质量的独立危险因素。Objective To analyze the relationship between serum levels of platelet-reactive protein(TSP)1,TSP2,aquaporin(AQP)4 and condition,prognosis in patients with cerebral hemorrhage.Methods A total of 100 patients with intracerebral hemorrhage treated between January 2016 and January 2020 were selected as the observation group in this study,and 100 healthy people who underwent physical examination were used as the control group,100 patients with cerebral infarction were served as disease control group.The levels of TSP1,TSP2,and AQP4 in the blood of the patients were measured.Logistic regression model was used to analyze the relationship between the levels of TSP1,TSP2 and AQP4 and the condition and prognosis of patients.Results The blood levels of TSP1,TSP2,and AQP4 in the observation group were significantly higher than those in the control group and the disease control group,and the differences were statistically significant(P<0.05).Meanwhile,there were significant differences in the levels of TSP1,TSP2 and AQP4 in the blood of different severity levels,the levels of various indicators in the severe group were the highest,and those in the low group were the lowest,and the differences were statistically significant(P<0.05).Compared with the group with poor prognosis,the levels of TSP1,TSP2 and AQP4 in the blood of the group with good prognosis were significantly lower,and the differences were statistically significant(P<0.05).The levels of TSP1,TSP2 and AQP4 in cerebral hemorrhage blood were independent influencing factors that affected the severity and prognosis of patients with cerebral hemorrhage(P<0.05).Conclusion Serum TSP1,TSP2 and AQP4 levels in patients with cerebral hemorrhage are abnormally elevated,and each index is also an independent risk factor that affects the severity of the patient′s condition and quality of prognosis.

关 键 词：脑出血 血小板反应蛋白1 血小板反应蛋白2 水通道蛋白4 病情 预后 

分 类 号：R544.1[医药卫生—心血管疾病] R743.34[医药卫生—内科学]