制备工艺对维生素B1片溶出行为的影响  

Effect of Preparation Technology on Dissolution Behavior of Vitamin B1 Tablets

作　　者：刘思聪 韩丹[1] 张大军[2] 张俊 肖燃 Liu Si-cong;Han Dan;Zhang Da-jun;Zhang Jun;Xiao Ran

机构地区：[1]沈阳医学院药学院,辽宁沈阳110034 [2]沈阳医学院药学院化学教研室,辽宁沈阳110034 [3]沈阳医学院法医司法鉴定所,辽宁沈阳110034

出　　处：《化工设计通讯》2020年第11期56-57,共2页Chemical Engineering Design Communications

基　　金：辽宁省重点研发项目(2017225058);沈阳医学院大学生科研项目(20198030);沈阳医学院大学生科研项目(20189014)。

摘　　要：目的:探索不同制备工艺对维生素B1溶出行为的影响。方法:以溶出度及在蒸馏水中溶出曲线为检测指标,考察粉末直压法、干法制粒压片、湿法制粒压片对维生素B1片溶出行为的影响。结果:采用粉末直压法、干法制粒压片、湿法制粒压片工艺制备的维生素B1片的溶出行为存在一定差异。结论:采用湿法制粒压片法制得的维生素B1片与市售参比制剂溶出行为一致,为维生素B1一致性评价工作奠定了基础。Objective:To explore the effect of different preparation technology on the dissolution behavior of vitamin B1.Methods:the dissolution rate and dissolution curve in distilled water were used as test indexes to investigate the effects of powder direct pressing,dry granulation and wet granulation on on the dissolution behavior of vitamin B1 tablets.Results:the dissolution behavior of vitamin B1 tablets prepared by powder direct pressing,dry granulation and wet granulation were different.Conclusion:the dissolution behavior of vitamin B1 tablets prepared by wet granulation and compression method is consistent with that of commercial reference preparations,which lays a foundation for the consistency evaluation of vitamin B1.

关 键 词：维生素B1片 制备工艺 溶出度 

分 类 号：R917[医药卫生—药物分析学]