SARS-CoV-2对神经系统损害的研究进展  

Research progress in nervous system damage caused by SARS-CoV-2

作　　者：黄鹏[1,2] 唐黎[1,2] 任翼 刘利群[1,2] HUANG Peng;TANG Li;REN Yi;LIU Liqun(Department of Pediatrics,Second Xiangya Hospital,Central South University,Changsha 410011;Children’s Brain Development and Brain Injury Research Office,Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院儿科,长沙410011 [2]中南大学湘雅二医院儿童脑发育与脑损伤研究室,长沙410011

出　　处：《中南大学学报（医学版）》2020年第10期1247-1254,共8页Journal of Central South University ：Medical Science

基　　金：湖南省科技厅计划重点研发项目(2018SK2069);湖南省卫生健康委员会资助项目(B2018-0311)。

摘　　要：由严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-Co V-2)所引起的2019冠状病毒病(coronavirus disease 2019,COVID-19)疫情在全球大暴发。SARS-Co V-2感染除了可累及呼吸系统外,还可导致严重的神经系统损伤。研究表明SARS-Co V-2可通过血行和跨神经元途径入侵神经系统,并可能通过抑制细胞免疫、低氧血症及炎症作用,诱导神经元变性与细胞凋亡,以及血管紧张素转化酶2(angiotensin converting enzyme 2,ACE2)机制造成COVID-19患者的神经系统损害,导致患者颅内感染、中毒性脑病、急性脑血管疾病、肌肉损害、周围神经系统损伤、急性脊髓炎、脱髓鞘疾病或其他神经系统疾病。The coronavirus disease 2019(COVID-19) caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) has become a major outbreak in the world. SARS-Co V-2 infection can not only involve in the respiratory system, but also cause severe nervous system damage. Studies have shown that SRAS-Co V-2 can invade the nervous system through hematogenous and transneuronal pathways, and may cause nervous system damage in patients with COVID-19 by inhibiting cellular immunity, hypoxemia, inflammation,inducing neuronal degeneration and apoptosis, and angiotensin converting enzyme 2(ACE2) mechanism. It can lead to intracranial infection, toxic encephalopathy, acute cerebrovascular disease, muscle damage, peripheral nervous system injury, acute myelitis,demyelination disease or other nervous system diseases.

关 键 词：严重急性呼吸综合征冠状病毒2 2019冠状病毒病 神经系统 

分 类 号：R563.1[医药卫生—呼吸系统]