高血压患者合并抑郁的危险因素分析  

Risk factors analysis of depression in patients with hypertension

作　　者：刘丛洋 邹勇[1] 徐明月 矫磊 宫鑫[1] LIU Congyang;ZOU Yong;XU Mingyue;JIAO Lei;GONG Xin(Integrated Chinese and Western Medicine Department,the Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai,Shandong 264000,China;Emergency Center,the Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai,Shandong 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院中西医结合科,山东省烟台市264000 [2]青岛大学附属烟台毓璜顶医院急救中心,山东省烟台市264000

出　　处：《中国动脉硬化杂志》2020年第10期895-898,共4页Chinese Journal of Arteriosclerosis

基　　金：山东省中医药科技发展计划项目(2013ZDZK-131)。

摘　　要：目的通过对高血压合并抑郁患者群体指标的分析,探讨高血压患者合并抑郁的危险因素。方法选取高血压合并抑郁患者和单纯高血压患者各110例,收集并比较两组患者的一般资料及各血清因子水平。筛选单因素分析有统计学意义的变量进行多因素Logistic回归分析。结果单因素分析显示,高血压合并抑郁患者的皮质醇(Cor)和肾素前体(Rep)水平显著升高,血红素加氧酶1(HO-1)水平显著降低,差异有统计学意义(P<0.05),两组间其他指标差异无统计学意义。对单因素分析筛选出的上述3个变量采用非条件多因素Logistic回归分析发现,HO-1水平降低(OR=0.012,95%CI:0.001~0.251,P<0.01)和Rep水平升高(OR=5.979,95%CI:3.054~11.706,P<0.001)是高血压患者合并抑郁的重要危险因素。结论 HO-1水平下降和Rep水平升高是高血压患者合并抑郁的重要危险因素。Aim To investigate the risk factors of depression in patients with hypertension.Methods 110 patients with hypertension combined with depression and 110 patients with hypertension alone were enrolled in this study,and the general data and serum factor levels of the two groups of patients were collected and compared.Multivariate Logistic regression analysis was performed on the variables with statistical significance in univariate analysis.Results Univariate analysis showed that cortisol(Cor)and renin precursor(Rep)levels were significantly increased and heme oxygenase-1(HO-1)levels were significantly decreased in patients with hypertension combined with depression(P<0.05),but there was no significant differences in other indicators between the two groups.Multivariate Logistic regression analysis was used to analyze the three variables selected by univariate analysis.It was found that HO-1(OR=0.012,95%CI:0.001~0.251,P<0.01)and Rep(OR=5.979,95%CI:3.054~11.706,P<0.001)were the important risk factors of depression for patients with hypertension.Conclusion Low HO-1 level and high Rep level are the important risk factors of depression for patients with hypertension.

关 键 词：高血压 抑郁 危险因素 LOGISTIC回归分析 

分 类 号：R5[医药卫生—内科学]