排毒养颜胶囊对尿酸酶缺失大鼠的降血尿酸作用  

Paidu Yangyan Capsules Lowered Serum Uric Acid in Uricase-deficient Rats

作　　者：董鲜祥 范楠 云宇 陈欢 段为钢 DONG Xianxiang;FAN Nan;YUN Yu;CHEN Huan;DUAN Weigang(The Department of Pharmacology,School of Basic Medicine,Kunming Medical University,Kunming 650500,China;Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]昆明医科大学基础医学院药理学系,云南昆明650500 [2]云南中医药大学云南省中医药学分子生物学重点实验室,云南昆明650500

出　　处：《云南中医学院学报》2020年第3期1-4,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81860162)。

摘　　要：目的观察排毒养颜胶囊对尿酸酶缺失大鼠的降血尿酸作用。方法取7只体质量180~220 g的雄性尿酸酶缺失大鼠,灌胃排毒养颜胶囊悬液(0.42 g/kg),连续灌胃5 d。给药前和末次给药后2 h取血制备血清,用磷钨酸法测定血尿酸水平。同时收集给药前24 h和给药第5天24 h尿液和粪便,也用磷钨酸法测定排泄物中的尿酸含量并计算总量。结果对比给药前,给药5 d后大鼠的血尿酸水平显著降低(P<0.05),粪便中24 h尿酸总量显著增加(P<0.05),但24 h尿液中的尿酸总量反而有减少趋势,差异无统计学意义(P=0.109)。结论口服排毒养颜胶囊能通过增加尿酸在粪便中的排泄量而降低尿酸酶缺失大鼠的血尿酸水平。Objective To observe pharmacological effect of Paidu Yangyan(PDYY)capsules on lowering serum uric acid(SUA)in uricase-deficient rats.Methods Seven male uricase-deficient rats weighting 180-220 g were orally administrated with the suspension of PDYY capsule at the dose of 0.42 g/kg for 5 d.Before and 2 h after the fifth administration,collected the blood,urine and feces.The SUA,uric acid in urine and feces were determined by uric acid kits with the phosphotungstic acid method,then the total uric acid in urine and feces were calculated.Results Compared with those before administration,SUA was significantly lowered(P<0.05),and the total uric acid in feces in 5 d significantly increased(P<0.05).While,the total uric acid in urine in 5 d decreased without significance(P=0.109).Conclusion Orally administration of PDYY capsule was able to lower SUA,and the mechanism may be associated with increasing uric acid excretion via feces.

关 键 词：尿酸酶缺失大鼠 高尿酸血症 排毒养颜胶囊 通便排毒 

分 类 号：R285.5[医药卫生—中药学]