大连地区冠心病患者基线血脂水平及10年血脂变化与分析  

Serum lipids levels and trend analysis in patients with coronary heart disease in Dalian China

作　　者：徐晓晨 翟恒博 张波[1] 王燕娥[1] 刘俊[1] 董志超[1] XU Xiaochen;ZHAI Hengbo;ZHANG Bo;WANG Yan'e;LIU Jun;DONG Zhichao(Department of Cardiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;Department of Cardiology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China;Department of Cardiology,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]大连医科大学附属第一医院心内科,辽宁大连116011 [2]郑州大学附属郑州中心医院心内科,河南郑州450000 [3]北部战区总医院心内科,辽宁沈阳110016

出　　处：《大连医科大学学报》2020年第5期400-404,共5页Journal of Dalian Medical University

基　　金：辽宁省省直医院改革重点临床科室诊疗能力建设项目(LNCCC-D18-2015);大连市科技计划项目(2015E12SF168)。

摘　　要：目的分析大连地区冠心病患者的血脂基线水平及近10年的变化趋势。方法回顾性分析2013—2014年及2003—2004年入住大连医科大学附属第一医院心内科行冠状动脉造影术的患者4279例,分析冠心病患者血脂基线水平现况、在不同人群中的差别以及10年前后血脂的变化趋势。结果与10年前冠心病患者比较,2013—2014年冠心病患者高胆固醇(TC)血症的比例明显下降(7.8%vs.10.6%,P=0.019),TC及高密度脂蛋白胆固醇(HDL-C)水平明显下降(P均<0.001),甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及非高密度脂蛋白胆固醇(non-HDL-C)水平无显著差异(P均>0.05);2013—2014年女性冠心病患者TC、TG、LDL-C、HDL-C、non-HDL-C均高于男性患者(P均<0.05);随着年龄的增长,2013—2014年冠心病患者尤其是男性患者TC、TG、LDL-C、HDL-C、non-HDL-C水平均逐渐下降(P均<0.05),女性患者血脂水平变化不明显(P均>0.05)。结论与10年前相比,尽管大连地区冠心病患者近些年血脂水平呈下降趋势,但血脂组成构成并没有得到改善,应进一步重视冠心病患者不同性别、年龄的血脂变化。Objective To explore and analyze serum lipids levels and trend of change in patients with coronary heart disease(CHD)in recent decade in Dalian,China.Methods A retrospective analysis of 4279 patients,who were admitted and underwent coronary angiography at the First Affiliated Hospital of Dalian Medical University between2003—2004 and 2013—2014,was performed.Serum lipids levels were analyzed according to the CHD patients’gender,age,and disease patterns.The trends of serum lipid levels in patients with CHD were studied in recent decade.Results Compared to ten years ago,the percentages of patients with hypercholesterolemia in 2013—2014 decreased from 10.6% to 7.8%(P=0.019).The levels of TC and HDL-C in CHD patients in 2013—2014 were lower than those in 2003—2004(P<0.001),and there were no differences in the levels of TG,LDL-C and non-HDL-C(all P>0.05).Compared with male CHD patients,there were higher levels of TC,TG,LDL-C,HDL-C and non-HDL-C in female patients(P<0.05).With the increase of age,the levels of TC,TG,LDL-C,HDL-C and non-HDL-C were declined especially in male CHD patients(P<0.05)and there were no significant changes in female patients in 2013—2014(P>0.05).Conclusion There is a declining trend in several lipid profiles among Dalian CHD patients;however,there is no obvious improvement in the composition of blood lipid.Further attention should be paid to serum lipid changes in CHD patients with different genders and ages.

关 键 词：冠心病 血脂 趋势 

分 类 号：R541.4[医药卫生—心血管疾病]