不同种类声敏剂联合超声的抗肿瘤效果及作用机制研究进展  

Research progress on anti-tumor effect and mechanism of different types of sonosensitizers combined with ultrasound

作　　者：林默楠 吕岩红(综述)[1] 郑金华(审校)[1] LIN Mo-nan;Lü Yan-hong;ZHENG Jin-hua(Department of Human Anatomy and Tissue Embryo,Harbin Medical University,Harbin 150081,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学,哈尔滨150081

出　　处：《医学研究生学报》2020年第10期1105-1110,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81703040);黑龙江省博士后启动基金(LBH-Q17121)。

摘　　要：声敏剂是一种对于超声辐射具有增敏活性的分子物质,二者联合应用能有效抑制肿瘤,已经在多种肿瘤细胞系的体内、外研究中被证实。声敏剂主要分为卟啉类和非卟啉类声敏剂,它们在超声的刺激下能够产生-单线态氧或者羟基自由基等活性氧簇,从而诱导肿瘤细胞死亡。文章主要探讨了不同种类的声敏剂在肿瘤细胞内的富集程度,对比了它们联合超声产生活性氧的效率、抑瘤效果及生物学机制。Sonosensitizer is a kind of molecular substance with sensitizing activity to ultrasonic radiation.Combined application of sonosensitizer and ultrasound can inhibit tumor effectively,which has been proved in vivo and in vitro studies of various tumor cell lines.Sonosensitizer can be divided into porphyrins and non-porphyrins,and they can produce singlet oxygen or hydroxyl free radicals and other reactive oxygen species under the stimulus of ultrasonic to induce tumor cell death.The paper mainly discusses the enrichment degree of different kinds of sonosensitizers in tumor cells,and compares the generation efficiency of reactive oxygen species,anti-tumor effect and biological mechanism of them combined with ultrasound.

关 键 词：声敏剂 超声 抗肿瘤效应 

分 类 号：K730.5[历史地理—历史学]