免疫性抗体与卵巢储备功能低下的关系  

The Relationship Between Immune Antibodies and Low Ovarian Reserve

作　　者：张碧云 李蕾蕾 黄丽艳 苗竹林 孟艳辉 ZHANG Bi-yun;LI Lei-lei;HUANG Li-yan;MIAO zhu-lin;MENG Yan-hui(Guangdong Institute of Family Planning Science and Technology,Guangdong Provincial Family Planning Hospital,Guangdong Guangzhou 510660;National Health Commission Key Laboratory of Male Reproduction and Genetics,Guangdong Guangzhou 510660)

机构地区：[1]广东省计划生育科学技术研究所广东省计划生育专科医院,广东广州510660 [2]国家卫生健康委员会男性生殖与遗传重点实验室,广东广州510660

出　　处：《深圳中西医结合杂志》2020年第19期14-16,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广州市科学创新委员会科技计划项目资助课题(1563000217)。

摘　　要：目的:探讨免疫性抗体与卵巢储备功能下降(DOR)的关系。方法:选取2016年5月至2019年12月期间在广东省计划生育专科医院妇科门诊就诊的91例DOR者作为研究对象,将其作为观察组,另选取80例同期体检的卵巢功能正常的健康者为对照组,分别检测两组研究对象未孕状态下的血清抗卵巢抗体(AoAb)、抗心磷脂抗体(AcAb)、抗甲状腺球蛋白抗体(TG-Ab)及甲状腺过氧化物酶抗体(TPoAb)的检测值、阳性率。结果:两组研究对象的年龄、体质量指数(BMI)、雌二醇(E2)水平比较,差异均无统计学意义(P>0.05);观察组的卵泡刺激素(FSH)水平高于对照组,抗缪勒管激素(AMH)水平低于对照组,差异均具有统计学意义(P<0.05);两组研究对象的TG-Ab、TPO-Ab与AcAb水平与阳性率差异均无统计学意义(P>0.05);观察组AoAb水平与阳性率高于对照组,差异具有统计学意义(P<0.05)。结论:染色体核型正常的DOR患者可检测到自身免疫性抗体功能紊乱,检测AoAb对诊断DOR有重要意义。Objective To explore the relationship between immune antibodies and decreased ovarian reserve(DOR).Methods A total of 91 DOR patients who attended the gynecological outpatient clinic of Guangdong Family Planning Hospital from May 2016 to December 2019 were selected as the research object and used as the observation group.Another 80 patients with normal ovarian function were selected during the same period of physical examination.The subjects served as the control group,and the serum anti-ovarian antibodies(AoAb),anti-cardiolipin antibodies(AcAb),anti-thyroglobulin antibodies(TG-Ab)and thyroid peroxidase antibodies(TPoAb)detection value and positive rate.Results There was no significant difference in age,body mass index(BMI),and estradiol(E2)levels between the two groups of study subjects(P>0.05);the observation group had higher levels of follicle stimulating hormone(FSH)than the control In the group,the level of anti-Müllerian hormone(AMH)was lower than that in the control group,and the differences were statistically significant(P<0.05);there was no statistical difference in the levels and positive rates of TG-Ab,TPO-Ab and AcAb between the two groups Scientific significance(P>0.05);the AoAb level and positive rate of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion DOR patients with normal chromosomal karyotype can detect autoimmune antibody dysfunction,and the detection of AoAb is important for the diagnosis of DOR.

关 键 词：卵巢储备功能下降 抗卵巢抗体 抗心磷脂抗体 抗甲状腺球蛋白抗体 甲状腺过氧化物酶抗体 

分 类 号：R711.75[医药卫生—妇产科学]