《中国药典》中四个品种来源的陈皮挥发油对兔离体肠肌运动影响的比较  

Comparison of the effects of four kinds of orange peel volatile oil from the Chinese Pharmacopoeia on rabbit intestinal muscle movement in vitro

作　　者：罗小泉[1] 皮达 陈欢[1] 袁可望 章超 杨武亮[1] LUO Xiao-quan;PI Da;CHEN Huan;YUAN Ke-wang;ZHANG Chao;YANG Wu-liang(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Shanghai Gusen Pharmaceutical Co.,Ltd,Shanghai 201499,China)

机构地区：[1]江西中医药大学,江西南昌330004 [2]上海谷森医药有限公司,上海201499

出　　处：《时珍国医国药》2020年第6期1281-1285,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81760680;81460575);江西省自然科学基金(20171BAB205098)。

摘　　要：目的研究比较《中国药典》中四个品种来源(江西南昌、江西新干、广东新会和福建福州)的陈皮挥发油对兔离体肠肌运动的影响,初步探讨挥发油的作用机制。方法采用离体肠肌实验,用BL-420S生物机能分析系统记录陈皮挥发油部位对正常肠肌及加入工具药后肠肌的影响,采集肠肌的振幅与频率,计算出各抑制率。结果陈皮挥发油高、中、低剂量组对兔离体肠肌自发活动均有不同程度的抑制作用,其中温州蜜柑和福橘挥发油对十二指肠部位的作用有极显著性差异(P<0.01)。且对乙酰胆碱和磷酸组胺促进十二指肠收缩同样有抑制作用。结论陈皮挥发油对肠肌运动有抑制作用,作用部位可能在十二指肠。Objective To compare the effects of volatile oils from orange peel of four varieties(Jiangxi Nanchang,Jiangxi Xingan,Guangdong Xinhui and Fujian Fuzhou)in Chinese Pharmacopoeia on the movement of isolated rabbit intestinal muscles,and to explore the mechanism of volatile oils.Methods BL-420 S bio-functional analysis system was used to record the effects of the volatile oil part of orange peel on normal intestinal muscle and intestinal muscle after adding tool drug.The amplitude and frequency of intestinal muscle were collected and the inhibition rates were calculated.Results The volatile oil of Pericarpium citri Reticulata in the high,medium and low dose groups had different degrees of inhibition on the spontaneous activity of rabbit intestinal muscle in vitro,among which the volatile oil of Wenzhou mandarin orange and mandarin orange had extremely significant differences on the duodenum(P<0.01).In addition,acetylcholine and histamine phosphate can also inhibit duodenal contraction.Conclusion The effect of volatile oil from Pericarpium citri Reticulatae on intestinal motility may be located in the duodenum.

关 键 词：陈皮 挥发油 离体肠 

分 类 号：R285.5[医药卫生—中药学]