基于代谢组学的慢性心衰病证诊断研究述评  

Review of the diagnosis of chronic heart failure syndrome based on metabonomics

作　　者：钟森杰 李静 李琳[1] 黄淑敏 杨梦 邱宏 程彬 胡志希[1] ZHONG Senjie;LI Jing;LI Lin;HUANG Shumin;YANG Meng;QIU Hong;CHENG Bin;HU Zhixi(Diagnostic Institute of Traditional Chinese Medicine,Hu′nan University of Chinese Medicine,Hu′nan Province,Changsha410208,China)

机构地区：[1]湖南中医药大学中医诊断研究所,湖南长沙410208

出　　处：《中国医药导报》2020年第29期40-44,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81774208);湖南省自然科学基金项目(2019JJ50447)。

摘　　要：慢性心衰的病理过程中伴随着一系列代谢功能的复杂改变,代谢组学通过先进的检测技术与统计算法,可以从整体层面把握机体的代谢功能改变情况,现已成为心衰实验研究的常用手段。本文归纳总结代谢组学技术在慢性心衰病证诊断中的研究概况,基于“代谢性重构”理论阐述慢性心衰的代谢特征,探讨慢性心衰不同证候的代谢组学变化规律,认为代谢组学技术对心衰的病情评价及证型辨析具有一定的诊断价值。并对研究中存在的关键问题进行论述,提出规范统一研究标准、合理设计对照实验、注重心衰病证的动态过程研究等相应的思路,以期为后续研究提供借鉴。The pathological process of chronic heart failure is accompanied by a series of complex changes of metabolic function.Metabolomics can grasp the metabolic function changes of the body from the overall level through advanced detection technology and statistical algorithms,which has now become a common means of experimental research on heart failure.This article summarizes metabonomics technology in the diagnosis of chronic heart failure disease research,based on the theory of“metabolic remodeling”,the metabolic characteristics of chronic heart failure are expounded,and the metabonomics change rules of different syndromes of chronic heart failure are discussed.It is believed that metabonomics technology has certain diagnostic value for the assessment of heart failure and the discrimination of syndrome types of heart failure.In addition,the key problems in the study are discussed,and the corresponding ideas such as standardized and unified research standards,reasonable design of controlled experiments,and emphasis on the dynamic process research of heart failure syndrome are put forward,so as to provide reference for subsequent studies.

关 键 词：慢性心衰 代谢组学 生物标志物 诊断研究 

分 类 号：R259[医药卫生—中西医结合]