围绝经期妇女骨密度水平影响因素分析  

Analysis of influencing factors of bone mineral density in perimenopausal women

作　　者：顾虹[1] 耿晓丽 于娜[3] GU Hong;GENG Xiaoli;YU Na(Department of Nuclear Medicine,Baogang Hospital,Inner Mongolia Autonomous Region,Baotou014010,China;Department of Gynaecology and Obstetrics,Baogang Hospital,Inner Mongolia Autonomous Region,Baotou014010,China;Department of Scientific Research,Baogang Hospital,Inner Mongolia Autonomous Region,Baotou014010,China)

机构地区：[1]内蒙古包钢医院核医学科,内蒙古包头014010 [2]内蒙古包钢医院妇产科,内蒙古包头014010 [3]内蒙古包钢医院科研部,内蒙古包头014010

出　　处：《中国医药导报》2020年第29期77-80,共4页China Medical Herald

基　　金：内蒙古自治区自然科学基金项目(2016ms0810);内蒙古自治区包头市科技计划项目(2018C2007-3-5)。

摘　　要：目的分析围绝经期妇女骨密度水平的影响因素。方法选取2018年1月—2019年5月在内蒙古包钢医院妇产科就诊及体检的620例围绝经期妇女为研究对象,根据骨密度值将研究对象分为低骨量组(482例)和正常骨量组(138例)。测定入组对象的骨密度,血清雌二醇(E2)、卵泡刺激素(FSH)、甲状旁腺激素(PTH)水平,分析骨密度与年龄、体重指数(BMI)、E2、FSH、PTH的关系。结果两组年龄,BMI、E2、FSH、PTH水平比较,差异均有统计学意义(均P<0.05),而两组孕次、吸烟比例比较,差异无统计学意义(P>0.05)。围绝经期妇女骨密度与年龄,FSH、PTH水平呈负相关(r=-0.402、-0.421、-0.357,均P<0.05),与BMI、E2水平呈正相关(r=0.387、0.408,均P<0.05)。年龄(>50岁)、BMI(<24 kg/m2)、FSH(≥20 IU/L)、E2(<20 pg/mL)、PTH(≥30 pg/mL)是围绝经期妇女骨密度的危险因素(OR=2.061、2.100、2.765、2.818、2.748,均P<0.05)。结论围绝经期妇女骨密度与年龄,FSH、BMI、E2、PTH水平密切相关,其中高龄,高FSH、高PTH、低BMI、低E2水平是骨密度的独立危险因素。Objective To analyze the influencing factors of bone mineral density in perimenopausal women.Methods A total of 620 perimenopausal women who saw a doctor and had physical examination in the Department of Gynaecology and Obstetrics,Baogang Hospital of Inner Mongolia Autonomous Region from January 2018 to May 2019 were selected as the study subjects.According to bone mineral density,the subjects were divided into the low bone mass group(482 cases)and the normal bone mass group(138 cases).Bone mineral density,levels of serum estradiol(E2),follicle-stimulating hormone(FSH)and parathyroid hormone(PTH)of the enrolled subjects were measured,and the relationship between bone mineral density and age,body mass index(BMI),E2,FSH and PTH were analyzed.Results The differences in age,levels of BMI,E2,FSH and PTH between the two groups were statistically significant(all P<0.05),while the differences in pregnancy times and smoking rates between the two groups were not statistically significant(P>0.05).In perimenopausal women,bone mineral density was negatively correlated with age,levels of FSH and PTH(r=-0.402,-0.421,-0.357,all P<0.05),and positively correlated with BMI and E2 levels(r=0.387,0.408,all P<0.05).Age(>50 years old),BMI(<24 kg/m2),FSH(≥20 IU/L),E2(<20 pg/mL),and PTH(≥30 pg/mL)were risk factors for bone mineral density in perimenopental women(OR=2.061,2.100,2.765,2.818,2.748,all P<0.05).Conclusion Bone mineral density in perimenopausal women is closely related to age,levels of FSH,BMI,E2 and PTH.Among them,advanced age,high FSH,high PTH,low BMI and low E2 levels are independent risk factors of bone mineral density.

关 键 词：骨密度 围绝经期 血清雌二醇 卵泡刺激素 危险因素 

分 类 号：R580[医药卫生—内分泌]