微针加工技术的最新研究进展  

Latest Research Progress of Microneedle Processing Technology

作　　者：王洁 王欢 吴文渊 李以贵 Wang Jie;Wang Huan;Wu Wenyuan;Li Yigui(College of Sciences,Shanghai Institute of Technology,Shanghai 201418,China)

机构地区：[1]上海应用技术大学理学院,上海201418

出　　处：《微纳电子技术》2020年第11期918-930,946,共14页Micronanoelectronic Technology

基　　金：国家自然科学基金资助项目(51035005);上海市科技兴农重点攻关项目(沪农科创字(2018)第3-3号);上海市“联盟计划”资助项目(LM201929)。

摘　　要：微针作为一种新型经皮给药器具,在生物医学领域中有广泛的应用需求。结合UV-LIGA加工技术、湿法刻蚀技术、干法刻蚀技术和表面微加工技术等传统微电子机械系统(MEMS)加工技术,以及最近出现的3D打印技术、激光加工技术、拉延光刻技术和热压法等微针的特种加工技术,分析了国内外的微针制备的研究现状,简述了不同类型的微针在经皮给药应用中的优缺点,指出了微针在经皮给药中存在的技术瓶颈和解决方案,最后提出了微针在药物治疗系统、医学检测系统、智能药物的输送系统和传感器系统等方面的应用。As a new transdermal drug delivery appliance,microneedles have a wide range of application requirements in the field of biomedicine.Combined with traditional micro-electromechanical system(MEMS)processing technologies such as UV-LIGA processing,wet etching,dry etching,surface micromachining,as well as recent 3 D printing,laser processing,drawing lithography,hot embossing and other special processing technologies,the research status of the preparation of microneedles at home and abroad are analyzed,the advantages and disadvantages of different types of microneedles in the application of transdermal drug delivery are briefly described,and the existed technical bottlenecks and proposed solutions of microneedles in transdermal drug delivery are pointed out.Finally,the applications of microneedles in drug treatment systems,medical detection systems,intelligent drug delivery systems,sensor systems and so on are proposed.

关 键 词：微电子机械系统(MEMS)工艺 3D打印技术 激光加工技术 拉延光刻技术 经皮给药 

分 类 号：TH703[机械工程—仪器科学与技术] TN305.7[机械工程—精密仪器及机械]