中药厚朴现代药理研究进展  

Research Progress in Modern Pharmacology of Magnolia Officinalis

作　　者：谭珍媛[1] 邓家刚[1] 张彤 韦锦斌[1] 姚金霞 韦海施 TAN Zhen-yuan;DENG Jia-gang;ZHANG Tong;WEI Jin-bin;YAO Jin-xia;WEI Hai-shi(Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学,南宁530021

出　　处：《中国实验方剂学杂志》2020年第22期228-234,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西科技厅重点研发计划项目(桂科AB18221099);农作物废弃物功能成分研究协同创新中心开放课题(CICAR2019-P3)。

摘　　要：厚朴是我国常用中药,其性辛温、味苦,具有燥湿消痰、下气除满的作用。常用于湿阻脾胃、胸脘闷胀、纳谷不香、恶心、呕吐、腹痛腹胀等证。临床上治疗胃肠不适、纳呆等有较好效果。研究表明,厚朴主要含有酚性化合物、生物碱及挥发油等多种化学成分。厚朴酚、和厚朴酚等酚性化合物是其最主要的活性物质,其对消化、神经、心血管与呼吸系统等均具有明显的药理活性。其次对糖脂代谢也有较为明显的影响,此外,其还具用抗炎、镇痛、抗病原微生物、抗菌、抗肿瘤、抗氧化等作用。厚朴花除了主要含有厚朴酚与和厚朴酚等活性物质外,尚含有挥发油,与厚朴功效相似,作用力稍弱,临床上主要用于脾胃湿、胀满、胸脘痞闷等证;厚朴叶则除了含有厚朴酚与和厚朴酚等酚性化合物外,还含有挥发油、黄酮与多糖等多种化学成分,具有抗菌、抗氧化、舒张血管等药理作用,临床上用量加大可代替厚朴入药。该文主要对厚朴近5年的药理作用研究进行综述,为更好开发利用厚朴皮及其废弃物花与叶,进一步研发以其为主药的相关功能型产品提供参考,同时也为扩大中药资源提供新思路。Magnoliae Officinalis Cortex(MOC)is a commonly used traditional Chinese medicine(TCM)in China.It is spicy-warm in property and bitter in flavor.It has the effects in eliminating dampness,eliminating phlegm and removing fullness.It is commonly used for dampness obstruction to spleen and stomach,chest and epigastric distension,glutinous grains,nausea,vomiting,abdominal pain and abdominal distension.It has a good efficacy in treating gastrointestinal discomfort and anorexia in clinic.The results showed that MOC mainly contains phenolic compounds,alkaloids and volatile oil.Magnolol,honokiol and other phenolic compounds are the main active substances,with obvious pharmacological activities on digestive,nervous,cardiovascular and respiratory systems.In addition,it also has anti-inflammatory,analgesic,anti-bacterial,antitumor and anti-oxidation effects.Except for magnolol and honokiol and other active substances,MOC flowers also contain volatile oil,with a similar effect with MOC but a weaker function.It is mainly used for treating spleen and stomach dampness,fullness,chest and epigastric distension.In addition to magnolol and honokiol and other phenolic compounds,MOC leaves also contain volatile oil,flavonoids and polysaccharides and other chemical components,which have antibacterial,antioxidative,vasodilatory and other pharmacological effects.It can be used as medicine instead of MOC in clinic.In this paper,the pharmacology studies of MOC in recent 5 years was reviewed,in order to better develop and utilize magnolia bark and its waste flowers and leaves,and further develop relevant functional products with MOC as the main drug,while providing new ideas for expanding the resources of TCM.

关 键 词：厚朴 厚朴酚 和厚朴酚 药理作用 

分 类 号：R2-0[医药卫生—中医学] R22