针对性心理干预对难治性甲状腺癌靶向性治疗患者焦虑抑郁和生活质量的影响  

Effect of targeted psychological intervention on anxiety, depression and quality of life in patients with refractory thyroid carcinoma targeted therapy

作　　者：朱俊玲[1] 吴军 ZHU Junling;WU Jun(Department of Breast and Thyroid Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province,Wuhan430023,China;Department of Nursing,the People's Hospital of Kaizhou District.CQ,Chongqing405400,China)

机构地区：[1]华中科技大学同济医学院附属协和医院乳甲外科,湖北武汉430023 [2]重庆市开州区人民医院护理部,重庆405400

出　　处：《中国医药导报》2020年第28期165-168,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金资助项目(81702397)。

摘　　要：目的探讨针对性心理干预对难治性甲状腺癌靶向治疗患者焦虑抑郁及生活质量的影响。方法将2015年1月—2017年1月在华中科技大学同济医学院附属协和医院进行难治性甲状腺癌靶向治疗的60例患者按治疗时间记为单双数,随机平均分为干预组和对照组,每组30例。对照组采用一般健康教育,干预组在对照组的基础上进行针对性心理干预。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和欧洲癌症研究治疗组织癌症生命质量问卷(EORTC)QLQ-C30(v3.0)评价患者焦虑抑郁和生活质量。结果干预前,两组SAS、SDS及EORTC QLQ-C30(v3.0)比较,差异无统计学意义(P>0.05)。干预后,干预组SAS、SDS均降低,且均低于对照组,差异有统计学意义(P<0.05),对照组SDS评分低于干预前,差异有统计学意义(P<0.05);干预组EORTC QLQ-C30问卷中躯体功能、角色、情绪、社会、总健康水平、疲倦、疼痛、气促、失眠与干预前比较,差异均有统计学意义(均P<0.05),且EORTC QLQ-C30问卷中除经济困难与对照组比较,差异无统计学意义(P>0.05),其余指标比较,差异均有统计学意义(均P<0.05)。结论针对性心理干预可以改善难治性甲状腺癌靶向治疗患者的焦虑抑郁和生活质量。Objective To investigate the effect of targeted psychological intervention on anxiety,depression and quality of life in patients with refractory thyroid carcinoma targeted therapy.Methods A total of 60 patients who received targeted therapy for refractory thyroid cancer in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,from January 2015 to January 2017 were recorded as odd and even numbers according to the treatment time,they were randomly divided into the intervention group and the control group,with 30 patients in each group.The control group adopted general health education,and the intervention group carried out targeted psychological intervention on the basis of the control group.Anxiety,depression and quality of life were evaluated by the self-rating anxiety scale(SAS),self-rating depression scale(SDS)and the cancer quality of life questionnaire European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30(V3.0).Results Before intervention,there were no significant differences in SAS,SDS and EORTC QLQ-C30(v3.0)between the two groups(P>0.05).After intervention,SAS and SDS in the intervention group were all decreased,and the differences were statistically significant(P<0.05);SDS score in the control group was lower than that before intervention,and the difference was statistically significant(P<0.05).Physical function,role,emotion,society,total health level,fatigue,pain,shortness of breath,and insomnia in the intervention group were statistically significant(all P<0.05).In the EORTC QLQ-C30 questionnaire,there was no statistically significant difference(P>0.05)except for the economic difficulties and the comparison with the control group,and the other indicators showed statistically significant differences(all P<0.05).Conclusion Targeted psychological intervention can improve anxiety,depression and quality of life in patients with refractory thyroid cancer targeted therapy.

关 键 词：难治性甲状腺癌 靶向治疗 针对性心理干预 焦虑 抑郁 生活质量 

分 类 号：R473.74[医药卫生—护理学]