AngⅡ与类风湿关节炎动脉粥样硬化相关性的临床分析  

Clinical Analysis of the Relationship Between AngⅡ and Atherosclerosis in Rheumatoid Arthritis

作　　者：陶黎[1] 刘潇潇[1] 潘琳[1] 练颖 TAO Li;LIU Xiao-xiao;PAN Lin;LIAN Ying(Department of Hematology,Rheumatology and Immunology,Chengdu First People's Hospital,Chengdu,Sichuan Province,610023 China)

机构地区：[1]成都市第一人民医院血液风湿免疫科,四川成都610023

出　　处：《中外医疗》2020年第29期39-42,共4页China & Foreign Medical Treatment

摘　　要：目的探讨AngⅡ(血管紧张素Ⅱ,angiotensin Ⅱ)与类风湿关节炎动脉粥样硬化相关性的,从而找到新的预测类风湿关节炎心血管风险的指标。方法方便选取2017年9月-2019年9月在该科住院的20例RA患者组,正常人20名为对照组。对两组的AngⅡ和颈总动脉IMT进行对比分析。结果类风湿关节炎组AngⅡ水平(0.96±0.05)pg/mL均高于对照组(0.83±0.16)pg/mL,差异有统计学意义(P<0.05),同时AngⅡ越高,B超测定双侧颈总动脉中层内膜厚度(IMT)值越高(OR=0.95,P<0.001),提示AngⅡ越高发生心血管疾患的几率就越高。结论 AngⅡ与动脉粥样硬化成正相关,可能成为新的预测心血管疾病风险的指标。Objective To investigate the relationship between AngⅡ(angiotensin Ⅱ) and atherosclerosis in rheumatoid arthritis, so as to find new indicators for predicting the cardiovascular risk of rheumatoid arthritis. Methods 20 RA patients hospitalized in the department from September 2017 to September 2019. Control group: 20 normal subjects. The AngⅡ and common carotid artery IMT of the two groups were compared and analyzed. Results The level of AngⅡ in the rheumatoid arthritis group(0.96±0.05) pg/mL was higher than that in the control group(0.83±0.16)pg/mL, the difference was statistically significant(P<0.05), and the higher the AngⅡ, the B-ultrasonic measurement of bilateral common carotid artery media The higher the film thickness(IMT) value(OR=0.95, P<0.001), the higher the AngⅡ, the higher the risk of cardiovascular disease.Conclusion AngⅡ is positively correlated with atherosclerosis, so it may become a new indicator of cardiovascular disease risk.

关 键 词：AngⅡ 类风湿关节炎 动脉粥样硬化 

分 类 号：R4[医药卫生—临床医学]