门冬胰岛素联合二甲双胍对妊娠期糖尿病患者妊娠结局的临床分析  

Clinical Analysis of Insulin Aspart Combined with Metformin on Pregnancy Outcome of Patients with Gestational Diabetes

作　　者：虞琪 徐峰[1] YU Qi;XU Feng(Department of Obstetrics and Gynecology,the First People's Hospital of Nantong City,Nantong,Jiangsu Province,226000 China)

机构地区：[1]南通市第一人民医院妇产科,江苏南通226000

出　　处：《中外医疗》2020年第29期109-111,共3页China & Foreign Medical Treatment

摘　　要：目的探讨门冬胰岛素联合二甲双胍治疗妊娠期糖尿病(GDM)的临床效果。方法便利选取2018年5月—2019年5月该院收治的82例GDM患者,按随机数字表法分为两组,各41例。对照组予以门冬胰岛素治疗,观察组加用二甲双胍治疗。比较两组用药前与分娩前血糖水平、胱抑素C(Cys C)及同型半胱氨酸(HCY)水平,并对比两组妊娠结局。结果治疗前,两组FPG、HbA1c、2 hPG相比,差异无统计学意义(t=0.282,0.120,0.088,P=0.779,0.905,0.930);治疗后,观察组FPG、HbA1c、2 hPG水平为(4.03±0.29)mmol/L、(5.32±0.91)%、(5.58±0.47)mmol/L,低于对照组的(4.85±0.36)mmol/L、(6.24±0.87)%、(6.81±0.72)mmol/L,差异有统计学意义(t=11.358,4.679,9.160,P<0.05);治疗前,两组Cys C及HCY水平相比,差异无统计学意义(t=0.424,0.047,P=0.673,0.963);治疗后,观察组Cys C、HCY水平为(0.72±0.17)mg/L、(8.15±2.03)μmol/L,低于对照组的(0.85±0.21)mg/L、(10.17±2.32)μmol/L,差异有统计学意义(t=3.081,4.196,P<0.05);观察组不良反妊娠结局发生率为7.32%,低于对照组的24.39%,差异有统计学意义(χ2=4.479,P=0.034)。结论门冬胰岛素联合二甲双胍治疗可稳定GDM患者血糖水平,降低Cys C、HCY水平,减少不良妊娠结局。Objective To explore the clinical effect of insulin aspart combined with metformin in the treatment of gestational diabetes mellitus(GDM).Methods A total of 82 GDM patients admitted to the hospital from May 2018 to May 2019 were convenient selected and divided into two groups according to the random number table method,with 41 cases in each group.The control group was treated with insulin aspart,and the observation group was treated with metformin.The blood glucose levels,Cys C(Cys C)and homocysteine(HCY)levels were compared between the two groups before medication and before delivery,and the pregnancy outcomes of the two groups were compared.Results Before treatment,there was no significant difference between the two groups of FPG,HbA1c,2 hPG(t=0.282,0.120,0.088,P=0.779,0.905,0.930);after treatment,the observation group FPG,HbA1c,2 hPG levels were(4.03±0.29)mmol/L,(5.32±0.91)%,(5.58±0.47)mmol/L,lower than the control group(4.85±0.36)mmol/L,(6.24±0.87)%,(6.81±0.72)mmol/L,the difference was statistically significant(t=11.358,4.677,9.160,P<0.05);before treatment,there was no statistically significant difference between the two groups of Cys C and HCY levels(t=0.424,0.047,P=0.673,0.963);after treatment,the levels of Cys C and HCY in the observation group were(0.72±0.17)mg/L and(8.15±2.03)μmol/L,which were lower than those in the control group(0.85±0.21)mg/L and(10.17±2.32)μmol/L,the difference was statistically significant(t=3.081,4.196,P<0.05);the incidence of adverse anti-pregnancy outcomes in the observation group was 7.32%,which was lower than 24.39%in the control group,and the difference was statistically significant(χ2=4.479,P=0.034).Conclusion Insulin aspart combined with metformin therapy can stabilize the blood glucose level of patients with GDM,reduce the levels of Cys C and HCY,and reduce adverse pregnancy outcomes.

关 键 词：妊娠期糖尿病 门冬胰岛素 二甲双胍 妊娠结局 血糖水平 

分 类 号：R5[医药卫生—内科学]