血清降钙素原和C反应蛋白在小儿支气管哮喘合并感染患儿中的诊断价值  

Diagnostic Value of Serum Procalcitonin and C-reactive Protein in Children with Bronchial Asthma Combined with Infection

作　　者：谭颖 刘艳军 王艳华[1] 林琳[1] TAN Ying;LIU Yanjun;WANG Yanhua;LIN Lin(Department of Laboratory,Shenyang children's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市儿童医院检验科,辽宁沈阳110000

出　　处：《中国医药指南》2020年第28期56-58,共3页Guide of China Medicine

摘　　要：目的分析血清降钙素原和C反应蛋白在小儿支气管哮喘合并感染中的诊断价值。方法选取我院于2017年6月至2019年6月收治的支气管哮喘合并感染患儿65例,据患儿感染类型分为哮喘合并病毒感染组(n=32)及哮喘合并细菌感染组(n=33);据患儿感染严重程度分为一般感染组(n=35)和严重感染组(n=30);另选取同期于我院进行治疗的30例单纯支气管哮喘患儿为单纯哮喘组。统计并比较单纯哮喘患儿、不同感染类型及不同感染程度患儿血清降钙素原和C反应蛋白水平及阳性率的差异。结果哮喘合并细菌感染组患儿血清降钙素原和C反应蛋白水平及阳性率分别高于单纯哮喘组和哮喘合并病毒感染组(P <0.05),哮喘合并病毒感染组患儿血清降钙素原和C反应蛋白水平及阳性率高于单纯哮喘组(P <0.05)。随病情感染程度加重,血清降钙素原和C反应蛋白水平及阳性率呈上升趋势(P <0.05)。结论血清降钙素原及C反应蛋白可作为区分支气管哮喘患儿细菌感染与病毒感染的重要诊断指标之一,同时可通过观察血清降钙素原及C反应蛋白水平及阳性率判断患儿病情的发展及变化。Objective To analyze the diagnostic value of serum procalcitonin and C-reactive protein in children with bronchial asthma combined with infection.Methods Sixty-fi ve children with bronchial asthma combined with infection admitted to our hospital from June 2017 to June 2019 were selected.According to the infection types of the children,they were divided into asthma combined with virus infection group(n=32)and asthma combined with bacterial infection group(n=33).According to the severity of infection,the children were divided into general infection group(n=35)and severe infection group(n=30).In addition,30 children with simple bronchial asthma treated in our hospital during the same period were selected as the simple asthma group.The differences of serum procalcitonin and C-reactive protein levels and positive rates in children with simple asthma,different types of infection and diff erent degrees of infection were analyzed and compared.Results The levels of serum procalcitonin,C-reactive protein and positive rates of children in asthma combined with bacterial infection group were higher than those in the simple asthma group and asthma combined with viral infection group(P<0.05),and the levels of serum procalcitonin and C-reactive protein and positive rates of children in asthma combined with viral infection group were higher than those in the simple asthma group(P<0.05).The levels of serum procalcitonin,C-reactive protein and the positive rate increased with the aggravation of infection(P<0.05).Conclusion Serum procalcitonin and C-reactive protein can be used as one of the important diagnostic indicators to distinguish bacterial infection from viral infection in children with bronchial asthma,and the development and change of the disease can be judged by observing the serum procalcitonin and C-reactive protein levels and the positive rate.

关 键 词：支气管哮喘 感染 儿童 降钙素原 C反应蛋白 

分 类 号：R725.6[医药卫生—儿科]