围绝经期糖代谢异常升高与骨代谢异常的相关性分析  

Analysis of the correlation between abnormal increase of glucose metabolism and abnormal bone metabolism in perimenopausal period

作　　者：刘峰 刘军[1] LIU Feng;LIU Jun(Department of Orthopaedics,Xincheng District Branch of Xuzhou Central Hospital,Xuzhou,Jiangsu 221009,China)

机构地区：[1]徐州市中心医院新城区分院骨科,江苏徐州221009

出　　处：《安徽医药》2020年第11期2199-2202,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析围绝经期糖代谢异常升高与骨代谢指标的相关性,并探讨其临床意义。方法选取徐州市中心医院新城区分院2018年1-12月收治的围绝经期女性病人100例,其中围绝经期糖代谢异常升高50例为血糖异常组,围绝经期糖代谢正常50例为血糖正常组。比较两组血糖水平、骨形成指标[骨碱性磷酸酶(BALP)、骨钙素(BGP)]、骨吸收指标[Ⅰ型胶原联蛋白羧基末端肽(CTX1)、I型胶原氨基酸延长肽(tPINP)]、骨钙调节素(PTH)指标,并采用pearson相关法分析血糖异常组血糖水平与骨代谢指标的相关性。结果血糖异常组的BALP低于血糖正常组[(73.59±8.00)U/L比(96.33±12.55)U/L,t=4.997,P=0.000],血糖异常组的BGP[(21.06±2.19)ng/mL比(12.23±1.44)ng/mL]、CTX1[(56.63±3.79)ng/L比(41.67±2.13)ng/L]、tPINP[(55.76±3.78)ng/mL比(40.37±2.50)ng/mL]、PTH[(71.60±6.34)ng/L比(44.56±3.84)ng/L]均高于血糖正常组(P<0.05)。空腹血糖对比,血糖异常组高于血糖正常组[(9.39±1.99)mmol/L比(4.21±1.01)mmol/L,t=24.164,P=0.000]。血糖异常升高妇女的血糖水平与BALP呈负相关(r=-0.850,P=0.000),与BGP呈正相关(r=0.867,P=0.000)、与CTX1呈正相关(r=0.882,P=0.000),与tPINP呈正相关(r=0.881,P=0.000)、与PTH呈正相关(r=0.923,P=0.000)。结论围绝经期糖代谢异常升高妇女的骨代谢指标存在一定的异常,且血糖水平异常升高可能是围绝经期妇女骨代谢异常引起骨质疏松症的重要原因。Objective To analyze the correlation between abnormal increase of glucose metabolism and bone metabolism in perimenopausal women,and to explore its clinical significance.Methods A total of 100 perimenopausal female patients admitted to the Xincheng Branch of Xuzhou Central Hospital from January to December 2018 were selected.Among them,50 perimenopausal women with abnormal elevation of glucose metabolism and 50 perimenopausal women with normal glucose metabolism.Blood sugar level,bone formation index(BALP,BGP),bone resorption index(CTX1,tPINP)and osteocalcin(PTH)were measured and compared between the two groups.Pearson correlation method was used to analyze the correlation between blood sugar level and bone metabolism index in women with abnormal blood sugar.Results Compared with the normal blood glucose group,the BALP of the abnormal blood glucose group was lower than that of the normal blood glucose group[(73.59±8.00)U/L vs.(96.33±12.55)U/L,t=4.997,P=0.000],and the BGP[(21.06±2.19)ng/mL vs.(12.23±1.44)ng/mL],CTX1[(56.63±3.79)ng/L vs.(41.67±2.13)ng/L],tPINP[(55.76±3.78)ng/mL vs.(40.37±2.50)ng/mL],PTH[(71.60±6.34)ng/L vs.(44.56±3.84)ng/L]of the abnormal blood glucose group were higher than those of the normal blood glucose group(P<0.05).Compared with the normal group,the abnormal group was higher than the normal group[(9.39±1.99)mmol/L vs.(4.21±1.01)mmol/L,t=24.164,P=0.000].The blood sugar level of women with abnormal elevation of blood sugar was negatively correlated with BALP(r=-0.850,P=0.000),positively correlated with BGP(r=0.867,P=0.000),positively correlated with CTX1(r=0.882,P=0.000),positively correlated with tPINP(r=0.881,P=0.000),and positively correlated with PTH(r=0.923,P=0.000).Conclusion There are some abnormal bone metabolic indexes in perimenopausal women with abnormal elevation of glucose metabolism,and abnormal elevation of blood sugar levels may be an important cause of osteoporosis caused by abnormal bone metabolism in perimenopausal women.There are certain abnormalities in bone me

关 键 词：围绝经期/代谢 骨质疏松 葡萄糖代谢障碍 骨代谢 血糖 

分 类 号：R580[医药卫生—内分泌]