多组分合成在工科综合型有机实验教学中的实践  

Practice of multi-component reaction in engineering comprehensive organic experiment teaching

作　　者：齐燕[1] 刘永军[1] 于跃芹[1] 高洪涛[1] QI Yan;LIU Yongjun;YU Yueqin;GAO Hongtao(College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《实验室科学》2020年第5期49-51,55,共4页Laboratory Science

基　　金：山东省一流本科课程(项目编号:鲁教高函(2020)3号);山东省研究生教育优质课程(项目编号:SDYKC19087);青岛科技大学有机化学系列课程群本科高水平教学团队专项基金(项目编号:201707)。

摘　　要：以基础理论和基本实验技能为依托,同时强调学生文献检索和使用能力的培养,基于新工科理念设计并实践了与科研热点对接的多组分合成综合型实验,强化了化工类学生跨专业复合知识和技能训练。以文献中的取代咪唑多组分合成为例,通过对其方法进行筛选和改进,设计多组分反应并优化反应条件,实现了合成1,2,4,5-四取代咪唑的实验方案。引导学生分组进行了实验设计和实施,并探讨了综合型实验的实施效果。Based on basic theories and experimental skills,and in order to integrate and improve students’scientific knowledge,practicing skills and literature searching abilities,a comprehensive experiment involving with multi-component reaction of scientific research hotspot has been designed and realized.After modification of reported syntheses of imidazoles,a multi-component reaction was designed and reaction conditions were optimized,to realize the synthesis of 1,2,4,5-tetrasubstituted imidazoles.Incorporating with the concept of new engineering disciplines,the teaching effects of the projects,practice and teaching results are discussed.

关 键 词：综合型实验 多组分反应 咪唑 新工科 

分 类 号：O626.21[理学—有机化学]