美沙酮维持治疗对海洛因成瘾者脑网络度中心度影响的静息态fMRI研究  

Degree centrality of brain network in heroin addicts treated with methadone maintenance:a resting-state functional magnetic resonance imaging study

作　　者：薛久华 陈佳杰[1] 蔡关科 时宏 刘为 刘艳[1] 孟妍 李玮[1] 王玮 李强[1] XUE Jiuhua;CHEN Jiajie;CAI Guanke;SHI Hong;LIU Wei;LIU Yan;MENG Yan;LI Wei;WANG Wei;LI Qiang(Department of Radiology,Tangdu Hospital,Air Force military Medical University,Xi'an 710038,China;Department of Radiology,Xi'an First Hospital,Xi'an 710002,China;Department of Advertisinng,Shaanxi Youth Vocational College,Xi'an 710068,China)

机构地区：[1]空军军医大学唐都医院放射科,西安710038 [2]西安市第一医院放射科,西安710002 [3]陕西青年职业学院,西安710068

出　　处：《磁共振成像》2020年第11期961-965,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81671661)。

摘　　要：目的探讨美沙酮维持治疗对海洛因成瘾者脑网络核心节点的影响。材料与方法招募26名海洛因成瘾短期戒断者(heroin abstinence,HA)与25名美沙酮维持治疗6个月余的海洛因成瘾者(methadone maintenance treatment,MMT)及42名健康对照者(health control,HC)。对三组被试进行静息态功能磁共振数据采集。基于图论理论分析比较三组被试大脑度中心度(degree centrality,DC)值差异,并分析差异脑区DC值与海洛因成瘾史及美沙酮治疗史的相关性。结果MMT组和HC组左内侧前额叶及双侧顶下小叶DC值均低于HA组,MMT组左侧楔前叶比HC组显著性增高,HA组与MMT组左侧眶额回、左侧额中回DC值均比HC组显著性增高,MMT组右侧岛叶比HC组、HA组显著性降低(P<0.001,Alphasim校正后P<0.05,体素>25)。结论美沙酮维持治疗可能有利于海洛因成瘾者自我意识、自我监测等功能的恢复。但突显性、决策制定、抑制性控制等功能仍存在异常,也许需要更长的时间或其他综合性的干预措施才能恢复。Objective:To explore the effect of methadone maintenance treatment on the core nodes of the brain network of heroin addicts.Materials and Methods:Twenty-six heroin addicts during short-term abstinence(HA),25 heroin addicts during methadone maintenance treatment(MMT)and 42 health controls(HC)were recruited.The resting-state fMRI data of all subjects were collected.Based on the theory of graph theory,the degree centrality(DC)of whole brains of the three groups were compared.The correlations between the DC values and history of heroin addiction and MMT were also analyzed.Results:The DC value of left medial frontal cortex and bilateral inferior parietal lobules in MMT and HC group was significantly lower than that in HA group.The DC value of left anterior precuneus lobe in MMT group was significantly higher than that in HC group.It was found that the DC value of left orbital frontal gyrus and left middle frontal gyrus in HA group and MMT group was significantly higher than that in HC group.The right insular lobe in MMT group was significantly lower than that in HC group and HA group(P<0.001,P<0.05 after Alphasim correction,voxels>25).Conclusions:The methadone maintenance treatment is beneficial to the recovery of self-awareness,self-monitoring of heroin addicts.However,there are still some abnormalities such as salience,decision-making and inhibitory control,which may take longer or other comprehensive interventions to recover.

关 键 词：美沙酮维持治疗 海洛因成瘾 度中心度 脑网络 功能磁共振 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]