1~3岁幼儿孤独谱系障碍脑形态异常的磁共振研究  

Magnetic resonance imaging on morphological abnormalities of brain in 1-3 years old children with autism spectrum disorder

作　　者：刘炳光[1] 曹满瑞[1] 朱志军[1] 刘阳[1] 万国斌[2] LIU Bingguang;CAO Manrui;ZHU Zhijun;LIU Yang;WAN Guobin(Department of Radiology,Affiliated Shenzhen Maternity and Child Healthcare Hospital,Southern Medical University,Shenzhen 518028,China;Department of Child Psychology and Rehabilitation,Affiliated Shenzhen Maternity and Child Healthcare Hospital,Southern Medical University,Shenzhen 518028,China)

机构地区：[1]南方医科大学附属深圳市妇幼保健院放射科,深圳518028 [2]南方医科大学附属深圳市妇幼保健院儿童心理与康复科,深圳518028

出　　处：《磁共振成像》2020年第11期990-993,998,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的基于体素形态学(voxel-based morphometry,VBM)分析1~3岁婴幼儿孤独谱系障碍(autism spectrum disorder,ASD)的脑形态异常,初步探讨磁共振成像早期诊断ASD的可行性。材料与方法对首次诊断为ASD幼儿及同期年龄、性别相匹配的健康婴幼儿行MRI高分辨率三维T1WI(3D T1WI)扫描。基于matlab2012b平台的统计参数图(SPM12)软件的工具包CAT12行3D T1WI图像VBM分析,计算各脑区的体积。采用两独立样本t检验比较两组全脑和各脑区体积差异。结果符合条件ASD组17例,均为男性,月龄12~34个月,平均(28.9±9.5)个月。对照组12例,均为男性,月龄13~35个月,平均(28.6±10.5)个月。与对照组比较,ASD组脑灰质体积、脑皮层厚度较大,脑脊液体积较小(P<0.05);ASD幼儿左中央后回,右顶下回和左额下回灰质体积较对照组增大(P<0.001,核团>100个体素)。结论婴幼儿ASD脑形态异常有一定特征,MRI有望成为早期诊断ASD的手段。Objective:To analyze morphological abnormalities of brain in 1-3 years old children with autism spectrum disorder(ASD)based on voxel-based morphometry(VBM),and to explore the feasibility of early diagnosis of ASD by magnetic resonance imaging(MRI)preliminarily.Materials and Methods:One to three years old children diagnosed first with ASD and age and gender matched normal children were scanned by MRI with high resolution 3D T1WI.Based on the statistical parameter graph(SPM12)with toolkit CAT12 of matlab2012b,VBM was used to analyze 3D T1WI images and the volume of each brain regions were calculated.The two sample t test was used to analyze differences of the volume of the whole brain and each brain regions.Results:There were eligible 17 cases in ASD group[All were male,with an average age of(28.9±9.5)months ranging from 12 to 34 months]and 12 cases in control group[All were male,with an average age of(28.6±10.5)months ranging from 13 to 35 months].Compared with the control,the gray matter volume and cerebral cortex thickness of the ASD group were larger,and the cerebrospinal fluid volume was smaller(P<0.05).The volume of gray matter in left posterior central gyrus,right inferior parietal gyrus and left inferior frontal gyrus were showed increased in 1-3 years old children with ASD(P<0.001,Nuclear group>100 voxels).Conclusions:There are certain characteristics of morphological abnormalities of brain in 1-3 years old children with ASD.MRI is expected to be a method of early diagnosis of ASD.

关 键 词：孤独症谱系障碍 磁共振成像 体素形态学 早期诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学] R651.l[医药卫生—诊断学]