线粒体异常与复发性流产  

Mitochondrial Abnormalities and Recurrent Abortion

作　　者：黄慧群 陆浩天 纪冬梅(审校) HUANG Hui-qun;LU Hao-tian;JI Dong-mei(Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,First Clinical College of Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖中心,安徽医科大学第一临床学院,合肥230032

出　　处：《国际生殖健康／计划生育杂志》2020年第6期490-494,共5页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(81971455)。

摘　　要：复发性流产是临床上常见的妊娠期并发症,也是妇产科中较为棘手的疾病之一,严重影响患者的身心健康与生活质量,但是其发病原因仍不清楚。线粒体是为细胞活动提供能量的细胞器,大量证据显示了线粒体在卵母细胞发育中的重要作用,越来越多研究也表明线粒体异常与复发性流产有关。维持线粒体的功能对早期胚胎发育至关重要。线粒体DNA(mtDNA)异常包括mtDNA拷贝数异常和mtDNA突变,可导致胚胎发育异常。线粒体自身功能障碍引起ATP和活性氧簇(ROS)异常、诱导细胞凋亡,也影响胚胎发育。现就mtDNA异常和线粒体功能障碍两个方面与复发性流产的发生发展作一综述,希望有助于复发性流产患者的临床诊治。Recurrent abortion,a common pregnancy complication,is one of the more intractable diseases in obstetrics and gynecology.It is a difficult disease affecting the physical and mental health and the life quality of patients.However,the cause of the disease is still unclear.Mitochondria are the organelles that provide energy for cell activities.A lot of evidence shows that mitochondria play an important role in oocyte development.More and more studies also show that mitochondrial abnormality is related to recurrent abortion.Therefore,the maintenance of mitochondrial function is crucial for early embryonic development.Mitochondrial DNA(mtDNA)abnormalities,such as mtDNA copy number abnormalities and mtDNA mutations,may lead to abnormal embryonic development.Moreover,the ATP and ROS abnormalities caused by mitochondrial dysfunction,and the apoptosis that followed,also affect the embryonic development.In this article review,we discuss the relationship between mtDNA abnormalities,mitochondrial dysfunction and the occurrence and development of recurrent miscarriage,so as to improve the clinical diagnosis and treatment of recurrent abortion.

关 键 词：流产 习惯性 线粒体 DNA 线粒体 细胞凋亡 氧化磷酸化 腺苷三磷酸 电子转运 

分 类 号：R714.21[医药卫生—妇产科学]