脑出血患者应用头颅局部亚低温联合依达拉奉治疗的效果探究  

Effect of Local Hypothermic Combined with Edaravone in Patients with Intracerebral Hemorrhage

作　　者：郑雪梅 ZHENG Xuemei(Yanbian University Affiliated Hospital,Yanbian Korean Autonomous Prefecture,Jilin 133002,China)

机构地区：[1]延边大学附属医院,吉林延边朝鲜族自治州133002

出　　处：《大医生》2020年第11期69-71,共3页Doctor

摘　　要：目的分析脑出血患者应用头颅局部亚低温联合依达拉奉的临床治疗效果。方法选取延边大学附属医院2019年1月至2020年1月收治的脑出血患者70例作为研究对象,随机数字表法分为对照组(35例)与观察组(35例)。对照组患者采取依达拉奉治疗,观察组则在对照组的基础上增加头颅局部亚低温治疗。比较两组患者治疗前后神经功能缺损程度评分、格拉斯哥昏迷评分、日常生活活动能力指数(BI指数)、脑血肿体积和水肿体积、肿瘤坏死因子-α及白细胞介素-1β等指标。结果治疗前,两组患者的神经功能缺损程度评分、格拉斯哥昏迷评分、BI指数、脑血肿体积和水肿体积、肿瘤坏死因子-α及白细胞介素-1β比较,差异均无统计学意义(P>0.05);治疗后,两组患者的神经功能缺损程度评分、脑血肿体积和水肿体积、肿瘤坏死因子-α及白细胞介素-1β均显著降低,且观察组显著低于对照组,而格拉斯哥昏迷评分、BI指数显著高于对照组,组间比较差异有统计学意义(P<0.05);观察组整体治疗效果高于对照组,组间比较差异有统计学意义(P<0.05)。结论脑出血患者采用头颅局部亚低温联合依达拉奉治疗临床效果确切,可有效改善患者的血清学指标和神经功能,促进患者生活自理能力的提高。Objective To analyze the effect of local mild hypothermia combined with edaravone in the treatment of cerebral hemorrhage.Methods A total of 70 patients with intracerebral hemorrhage admitted,Yanbian University Affiliated Hospital from January 2019 to January 2020 as an object of study.According to the random method,the patients were divided into control group and observation group,35 cases in each group.The patients in the control group were treated with edaravone,while the observation group was treated with local mild hypothermia on the basis of the control group.The neurological deficit score,Glasgow Coma Score,Bi index,hematoma volume and edema volume,tumor necrosis factor-αand interleukin-1β,and overall efficacy were compared between the two groups before and after treatment.Results Before treatment,there were no statistically significant differences between the two groups in neurological deficit degree score,Glasgow coma score,BI index,cerebral hematoma volume and edema volume,tumor necrosis factor and interleukin-1(P>0.05).After treatment,the degree of nerve function defect score of two groups of patients,cerebral hematoma volume and edema volume,tumor necrosis factor alpha and interleukin 1 beta were significantly lower,and the observation group of patients were significantly lower than the control group,and Glasgow coma scale,BI index is significantly higher than the control group,compare the difference between groups was statistically significant(P<0.05);The overall treatment effect of the observation group was higher than that of the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion The clinical effect of partial hypothermia combined with edaravone in patients with cerebral hemorrhage was definite,which can effectively improve the serological indexes and nerve function of patients,and promote the self-care ability of patients.

关 键 词：脑出血 头颅 亚低温 依达拉奉 

分 类 号：R47[医药卫生—护理学]