益气温阳法治疗非小细胞肺癌口服EGFR-TKI所致腹泻的临床观察  

Clinical observation on Yiqi wenyang therapy for diarrhea caused by oral EGFR-TKI in non-small cell lung cancer

作　　者：刘姣林 闫磊[1] 邬雨春 张瑾[1] 李文奇[1] 刘利国 邢燕 郭永红[1] 付晓艳[1] LIU Jiao-lin;YAN Lei;WU Yu-chun;ZHANG Jin;LI Wen-qi;LIU Li-guo;XING Yan;GUO Yong-hong;FU Xiao-yan(l.Baotou Tumor Hospital,Baotou,Inner Mongolia 014000;Baotou Qing shan District 202 Hospital,Baotou,Inner Mongolia 014000)

机构地区：[1]包头市肿瘤医院,内蒙古包头014000 [2]包头市青山区二0二医院,内蒙古包头014000

出　　处：《内蒙古中医药》2020年第10期5-8,共4页Inner Mongolia Journal of Traditional Chinese Medicine

基　　金：包头市科技计划项目(2019Z3012-3)。

摘　　要：目的:观察益气温阳法治疗非小细胞肺癌口服EGFR-TKI所致腹泻的临床疗效。方法:选取2018年6月—2019年12月本院门诊及住院收治的60例服用EGFR-TKI后出现腹泻的非小细胞肺癌患者,随机分为治疗组和对照组,各30例。对照组予思密达、双歧杆菌等常规西药治疗,治疗组在常规西药治疗基础上给予益气温阳中药治疗。两组均治疗7d为1个疗程,2个疗程后评定疗效。结果:治疗组与对照组腹泻分级比较:有效率分别为96.7%(29/30)和80.0%(24/30),腹泻症状积分比较:有效率分别为86.7%(26/30)和56.7%(17/30),差异有统计学意义(P<0.05);腹泻各症状比较:治疗组腹泻、脘腹痞满、腹胀腹痛缓解的同时,在倦怠乏力、神疲懒言、口渴、畏寒肢冷等症状改善方面差异有统计学意义(P<0.05),对照组改善不明显;生活质量KPS评分,治疗组与对照组有效率分别为96.7%(29/30)和76.7%(23/30),差异有统计学意义(P<0.05)。结论:益气温阳法治疗非小细胞肺癌口服EGFR-TKI所致腹泻有显著疗效。Objective:To observe the clinical effect of Yiqi wenyang therapy on diarrhea caused by oral EGFR-TKI in non-small cell lung cancer.Methods:A total of 60 patients with non-small cell lung cancer who developed diarrhea after taking EGFR-TKI from June2018 to December 2019 were selected and randomly divided into treatment group and control group with 30 cases in each group.The control group was treated with Smecta,Bifidobacterium was treated with conventional western medicine,and the treatment group was treated with Yiqi wenyang traditional Chinese medicine on the basis of conventional western medicine.Both groups were treated for 7 days as a course of treatment,and the curative effect was evaluated after two courses of treatment.Results:Compared with the control group,the effective rates of the treatment group and the control group were 96.7%(29/30)and 80.0%(24/30),and the diarrhea symptom scores were 86.7%(26/30)and 56.7%(17/30),with significant differences(P<0.05).Comparison of symptoms of diarrhea:while relieving diarrhea,epigastric fullness,abdominal distension and abdominal pain,the treatment group showed statistically significant improvement in symptoms such as lassitude,fatigue,listlessness,thirst,aversion to cold and limb coldness(P<0.05),while the control group showed no significant improvement.The KPS score of quality of life showed that the effective rates of the treatment group and the control group were 96.7%(29/30)and 76.7%(23/30),the difference was statistically significant(P<0.05).Conclusion:Yiqi wenyang method is effective in treating diarrhea caused by oral EGFR-TKI in non-small cell lung cancer.

关 键 词：益气温阳 非小细胞肺癌 EGFR-TKI 腹泻 

分 类 号：R273[医药卫生—中西医结合]