大黄苷元的药代动力学研究概况  

Research Progress on Pharmacokinetics of Rhubarb Aglycones

作　　者：高聪聪 薛浩特 GAO Congcong;XUE Haote(Department of Pharm acy,Zhengzhou People's Hospital,Henan Province,Zhengzhou 450000,China;Xiuwu County Food and Drug Inspection Office,Henan Province,Xiuwu 454350,China)

机构地区：[1]郑州市人民医院药学部,河南郑州450000 [2]修武县食品药品检验所质检部,河南修武454350

出　　处：《光明中医》2020年第20期3306-3308,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：大黄苷元是大黄中主要的活性成分之一,具有抗炎、抗肿瘤、抗氧化应激、抗病毒、减轻延缓疼痛等功效。本文整理近年来有关大黄苷元药代动力学研究的文献,从分析方法、研究现状2个方面对大黄苷元的药代动力学过程进行归纳总结,并对大黄苷元药代动力学的前景进行研究,以期有助于深入研究大黄苷元的代谢机制及途径,指导临床合理用药。Rhubarb aglyside is one of the main active ingredients in rhubarb,which has anti-inflammatory,anti-tumor,anti-oxidative stress,anti-virus,relieving and delaying pain and other effects.In this paper,literatures on the pharmacokinetics of rhubarb aglycones in recent years were reviewed,and the pharmacokinetics of rhubarb aglycones were summarized from two aspects of analysis method and research status,and the development prospect of rhubarb aglycones pharmacokinetics was studied.It is expected to be helpful to further study the metabolic mechanism and pathway of rhubarb aglycogen and to guide clinical rational drug use.

关 键 词：大黄 大黄苷元 药代动力学 色谱法 综述 

分 类 号：R285.5[医药卫生—中药学]