理气化痰、和胃利胆中药治疗气滞型肝癌肝动脉化疗栓塞术后栓塞综合征  

Clinical Observation on the Treatment of Post TACE Syndrome of Liver Cancer with Stagnation of Qi by Chinese Herbs

作　　者：葛时序 于倩 王亚华[1] 李辉 王聃 孟健[2] 申磊 GE Shixu;YU Qian;WANG Yahua;LI Hui;WANG Dan;MENG Jian;SHEN Lei(Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,Hebei Province,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China;Fengtian Hospital of Traditional Chinese Medicine,Shenyang 110000,China)

机构地区：[1]唐山市中医医院,河北唐山063000 [2]辽宁中医药大学附属医院,沈阳110000 [3]奉天中医院,沈阳110000

出　　处：《吉林中医药》2020年第10期1323-1326,共4页Jilin Journal of Chinese Medicine

基　　金：国家科技支撑计划(2012BAI25B04);河北省中医药管理局科研项目(2019224)。

摘　　要：目的探讨理气化痰、和胃利胆中药对气滞型肝癌肝动脉化疗栓塞术(TACE)后栓塞综合征的影响。方法选择2017年6月-2019年3月唐山市中医医院肿瘤科肝癌患者72例作为研究对象,采用随机、双盲、平行对照的原则,分为试验组与对照组各36例。对照组给予肝动脉化疗栓塞术加西药治疗,试验组在对照组基础上加用理气化痰、和胃利胆中药治疗。比较2组患者栓塞术后综合征发生情况、肝功能、患者生存质量。结果治疗后2组白蛋白(ALB)水平降低(P <0.05),丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平升高(P <0.05),且试验组ALB水平高于对照组(P <0.05),ALT、AST、TBIL水平低于对照组(P <0.05);试验组栓塞术后综合征发生情况明显少于对照组(P <0.05);治疗前2组的KPS评分无明显差异(P> 0.05),2组治疗后与治疗前比较均有明显差异(P <0.05);结论理气化痰、和胃利胆中药能够预防肝癌患者肝动脉化疗栓塞术后栓塞综合征的发生,缓解临床症状,减轻化疗对肝脏的损害,有利于延长生存期。Objective To investigate the effect of Chinese herbs for regulating qi and resolving phlegm on embolic syndrome after transcatheter arterial embolization(TACE) for liver cancer of qi stagnation type. Methods 72 patients with liver cancer in the oncology department of Tangshan Hospital of Traditional Chinese Medicine from June 2017 to March 2019 were selected and randomly divided into experimental group and control group with 36 cases in each group. The control group was treated with TACE and Western medicine, while the experimental group was treated with Liqihuatan Heweilidan promoting herbs on the basis of the control group. The incidence of PES, liver function and quality of life were compared between the two groups. Results after treatment, the levels of ALB level decreased(P<0.05), ALT,AST, TBIL levels increased(P<0.05), and the ALP level in the experimental group was higher than that in the control group(P<0.05), and the levels of alt, AST, TBIL in the experimental group were lower than those in the control group(P<0.05);the occurrence of PES in the experimental group was significantly less than that in the control group(P<0.05);KPS in the two groups before treatment was significantly lower than that in the control group(P<0.05) There was no significant dif ference in scores between the two groups(P>0.05), but there were significant dif ferences between the two groups after treatment and before treatment(P<0.05). Conclusion The traditional Chinese medicine of regulating qi and resolving phlegm, harmonizing stomach for promoting bile flow can prevent the occurrence of syndrome after TACE in patients with liver cancer, alleviate the clinical symptoms, reduce the damage to liver caused by chemotherapy, and prolong the survival period.

关 键 词：肝癌 理气化痰 和胃利胆 动脉栓塞术 

分 类 号：R273[医药卫生—中西医结合]