琥珀酸美托洛尔缓释片联合辛伐他汀治疗冠心病心绞痛的疗效及对心功能、血LTBP-2、Hcy的影响  

Effect of metoprolol succinate sustained-release tablets combined with simvastatin on angina pectoris of coronary heart disease and cardiac function,blood LTBP-2 and Hcy

作　　者：李小琴[1] LI Xiaoqin(Department of Internal Medicine,the Second People’s Hospital of Jiyuan City,He’nan Jiyuan 459000,China)

机构地区：[1]济源市第二人民医院内一科,河南济源459000

出　　处：《上海医药》2020年第21期17-20,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨琥珀酸美托洛尔缓释片合辛伐他汀治疗冠心病心绞痛疗效。方法:前瞻性选取88例冠心病心绞痛患者,随机数字表法分组,各44例。单药组予以琥珀酸美托洛尔缓释片,联合组加用辛伐他汀,比较两组疗效。结果:联合组总有效率、心脏指数(CI)、E峰流速/A峰流速(E/A)、心排血量(CO)高于单药组,潜在转化生长因子结合蛋白2(LTBP-2)、同型半胱氨酸(Hcy)低于单药组(P<0.05)。结论:琥珀酸美托洛尔缓释片合辛伐他汀治疗冠心病心绞痛疗效显著。Objective:To explore the efficacy of metoprolol succinate sustained-release tablets combined with simvastatin in the treatment of coronary heart disease and angina pectoris.Methods:Eighty-eight patients with coronary heart disease and angina pectoris were prospectively selected and divided into a monotherapy group and a combination group with 44 cases each according to the random number table method.The monotherapy group was treated with metoprolol succinate sustained-release tablets and the combination group with both metoprolol succinate sustained-release tablets and simvastatin.The efficacy was compared between the two groups.Results:The total effective rate,cardiac index(CI),E-peak velocity/A-peak velocity(E/A),and cardiac output(CO)were higher while the potential transforming growth factor binding protein 2(LTBP-2)and homocysteine(Hcy)levels were lower in the combined group than the monotherapy group(P<0.05).Conclusion:Metoprolol succinate sustained-release tablets combined with simvastatin are effective in the treatment of coronary heart disease and angina pectoris.

关 键 词：心功能 琥珀酸美托洛尔缓释片 辛伐他汀 冠心病心绞痛 

分 类 号：R972.6[医药卫生—药品] R542.2[医药卫生—药学]