PPARGC1A基因多态性与中国汉族人群2型糖尿病患者肾脏疾病风险的研究  

Association Between PPARGC1A Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type2 Diabetes Mellitus in a Chinese Han Population

作　　者：刘鹏 赵海玲[2] 马亮[3] 申正日 邱新萍 李平[2] LIU Peng;ZHAO Hailing;MA Liang(Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing,101300)

机构地区：[1]北京中医医院顺义医院,北京101300 [2]中日友好医院临床医学研究所,免疫炎性疾病北京市重点实验室,北京100029 [3]中日友好医院临床实验室,北京100029

出　　处：《中国中西医结合肾病杂志》2020年第10期866-870,共5页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然科学基金青年项目(No.8190152536);国家自然科学基金国际(地区)合作与交流项目(No.81620108031)。

摘　　要：目的:探讨糖尿病(diabetes mellitus,DM)患者中PPARGC1A rs8192678(G>A)基因多态性与糖尿病肾病(Diabetic kidney disease,DKD)风险的相关性。方法:利用TaqMan SNP基因分型分析DM与DKD患者rs8192678基因多态性,进行卡方检验和多变量逻辑回归分析,评估rs8192678与DKD易感性之间的关联。结果:次要等位基因(A)与DKD低风险之间存在显著相关性(P<0.02)。在显性模型中,与GG基因型相比,GA+AA基因型的DKD风险显着降低(P=0.007);在加性模型中,与GG基因型相比,GA和AA基因型的DKD风险显着降低(P=0.027)。在亚组分析中,TC正常组显性模型GG较GA+AA基因型的DKD风险显着降低(P=0.018);在TG正常组显性模型中,GG较GA+AA基因型的DKD风险显着降低(P=0.001);在加性模型中,GG较GA和AA基因型的DKD风险显着降低(P=0.001)。结论:中国汉族人群糖尿病患者中PPARGC1A rs8192678等位基因A与DKD的低风险显著相关。Objective:We designed a case-control study and selected PPARGC1A rs8192678 polymorphisms to determine the correlation between these polymorphisms and diabetic kidney disease(DKD)susceptibility in a Chinese Han population.Methods:305 DKD patients and 355 type2 diabetes mellitus(DM)patients without kidney disease were recruited.Results:Our results showed that r rs8192678 was associated with DKD(genotype,P=0.026;allele,P=0.016).The rs8192678 was associated with a higher risk of DKD under a dominant model(P=0.007)and an additive model(P=0.027).In subgroup analysis of patients without hypercholesterolemia,the rs8192678 was associated with increased risk of DKD under a dominant model adjustment for age and sex(P=0.018).In subgroup analysis of patients without hypertriglyceride,the rs8192678 was associated with increased risk of DKD under a dominant model adjustment for age and sex(P=0.001)and an additive model(P=0.001).Conclusion:Our results suggest that PPARGC1A rs8192678 is significantly associated with a higher risk of DKD in Chinese Han individuals.

关 键 词：PPARGC1A基因 rs8192678 糖尿病肾病 糖尿病 基因多态性 

分 类 号：R692.9[医药卫生—泌尿科学] R587.2[医药卫生—外科学]