Corvis■ST在青光眼中测量中央角膜厚度和眼内压的临床研究  

Clinical study on Corvis■ST for measuring corneal thickness and intraocular pressure in glaucoma

作　　者：朱小敏 张勇[2] 谢琳 ZHU Xiaomin;ZHANG Yong;XIE Lin(Department of Ophthalmology,Third Affiliated Hospital of Chongqing Medical University,Chongqing 401120,China;Department of Ophthalmology,82 Hospital of PLA,Huaian,Jiangsu 233000,China)

机构地区：[1]重庆医科大学附属第三医院眼科,401120 [2]中国人民解放军第八二医院眼科,江苏淮安233000

出　　处：《重庆医学》2020年第21期3556-3560,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81670860);重庆市自然科学基金项目(cstc2018jcyjAX0034)。

摘　　要：目的探讨Corvis■ST在青光眼患者中测量眼内压和中央角膜厚度(CCT)的可靠性、准确性及临床应用价值。方法选择原发性青光眼患者共89例(131眼),根据CCT不同分为角膜正常组(CCT 520~580μm,n=78)、角膜变薄组(CCT<520μm,n=28)、角膜增厚组(CCT>580μm,n=25),分别用Corvis■ST、A型超声角膜厚度测量仪(A超)和Pentacam系统测量CCT并进行一致性比较。用Corvis■ST、非接触眼压计(NCT)、Goldmann压平眼压计(GAT)测量眼压并分析眼压值与CCT的相关性。结果Corvis ST、A超、Pentacam系统测得的CCT分别为(550.20±35.96)、(550.50±35.80)、(550.60±36.09)μm,三者测得的CCT比较差异无统计学差异(P>0.05)。Corvis■ST、GAT、NCT测得总平均眼压值分别为(18.79±4.22)、(18.93±4.30)、(18.96±4.39)mm Hg,三者测得的总平均眼压值比较差异无统计学意义(P>0.05),Person相关性分析发现总Corvis■ST测量眼压值与CCT无明显相关性(P>0.05),而总GAT、NCT测量眼压值与CCT有线性相关性(r2=0.455、0.497,P<0.001、0.001)。角膜正常组Corvis■ST、GAT、NCT测得眼压值比较差异无统计学意义(P>0.05),Corvis■ST、GAT、NCT与CCT均无明显相关性(P>0.05);角膜变薄组和角膜增厚组Corvis■ST与GAT、NCT测得眼压差值比较差异有统计学意义(P<0.05),两组患者GAT、NCT所测眼压值与CCT均有直线相关性(P<0.05),Corvis■ST所测眼压值与CCT均无线性相关性(P>0.05)。结论Corvis■ST测量CCT和眼内压在青光眼中有较好的临床价值。Objective To investigate the reliability,accuracy and clinical application value of Corvis■ST for measuring the intraocular pressure and central corneal thickness(CCT)in the patients with glaucoma.Methods A total of 89 patients with primary glaucoma(131 eyes)were selected and divided into the corneal normal group(CCT 520-580μm,n=78),the corneal thinning group(CCT<520μm,n=28)and the corneal thickening group(CCT>580μm,n=25)according to CCP.CCT was measured by using Corvis■ST,type A ultrasound corneal thickness meter(A ultrasound)and Pentacam system and the consistency comparison was conducted.The intraocular pressure(IOP)was measured by using Corvis■ST,Topcon non-contact tonometry(NCT),Goldmann applanation tonometry(GAT),and then the correlation between the intraocular pressure values with CCT was analyzed.Results CCT measured by Corvis■ST,A ultrasound and Pentacam system were(550.20±35.96),(550.50±35.80)and(550.60±36.09)μm respectively,the difference among the three instruments had no statistical significance(P>0.05).The total average IOP values measured by Corvis■ST,GAT and NCT were(18.79±4.22),(18.93±4.30)and(18.96±4.39)mm Hg respectively,the difference among the three values had no statistical significance(P>0.05).The Person correlation analysis found that the IOP value measured by Corvis■ST had no significant correlation with CCT(P>0.05),while the IOP value measured by GAT and NCT had a linear correlation with CCT(r=0.455,0.497,P<0.001,0.001).The measured IOP values had no statistical difference among Corvis■ST,GAT and NCT.Corvis■ST,GAT and NCT had no significant correlation with CCT(P>0.05).In the thinning group and thickening group,the IOP difference value between Corvis■ST with GAT and NCT had statistically significant difference(P<0.05).The IOP value measured by GAT and NCT had no linear correlation with CCT(P>0.05).Conclusion The CCT and IOP measured by Corvis■ST have good clinical value in glaucoma.

关 键 词：Corvis■ST 青光眼 眼内压 中央角膜厚度 A型超声 PENTACAM系统 

分 类 号：R320.37[医药卫生—人体解剖和组织胚胎学]