Paliperidone palmitate-induced facial angioedema:A case report  

作　　者：Maytinee Srifuengfung Thanisorn Sukakul Chanika Liangcheep Natee Viravan 

机构地区：[1]Department of Psychiatry,Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok 10700,Thailand [2]Department of Dermatology,Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok 10700,Thailand

出　　处：《World Journal of Clinical Cases》2020年第20期4876-4882,共7页世界临床病例杂志

摘　　要：BACKGROUND Paliperidone palmitate is a once-monthly injectable,atypical antipsychotic.To our knowledge,there has been only one report of paliperidone palmitate-induced angioedema presenting with acute laryngeal edema with subsequent respiratory arrest.Here,we present a case report of paliperidone palmitate-induced angioedema with a relatively mild clinical presentation compared with the previously reported case,and the patient's condition was not complicated by lifethreatening anaphylaxis.CASE SUMMARY A 79-year-old female,who had a major neurocognitive disorder due to Alzheimer's disease with behavioral disturbances.Paliperidone palmitate was offlabel used to control her aggression,irritability,and psychosis.After induction doses(150 mg and 100 mg intramuscularly,given 1 wk apart),she developed intermittent swelling of the face,eyelids,and lips on day 17 after the initial dose,and the edema was explicitly seen on day 20.The diagnosis was paliperidone palmitate-induced angioedema.The monthly injection dose was discontinued on day 33 after the initial dose.The angioedema was subsequently alleviated,and it had completely resolved by day 40 after the initial dose.CONCLUSION Paliperidone palmitate-induced angioedema is a rare condition and can present with a mild,intermittent facial edema,which may be overlooked in clinical practice.

关 键 词：Case report Paliperidone palmitate Paliperidone LAI Long-acting paliperidone ANGIOEDEMA 

分 类 号：R969[医药卫生—药理学]