小剂量低分子肝素钙对早发型重度子痫前期患者胎盘血流动力学指标及母婴结局的影响  

Effect of low-dose of low molecular weight heparin calcium on placental hemodynamic indexes and maternal and infant outcomes in patients with early onset severe preeclampsia

作　　者：白云 李雪兰[1] BAI Yun;LI Xuelan(the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710000,China)

机构地区：[1]西安交通大学第一附属医院,陕西西安710000

出　　处：《临床医学研究与实践》2020年第32期99-101,共3页Clinical Research and Practice

摘　　要：目的分析小剂量低分子肝素钙对早发型重度子痫前期患者胎盘血流动力学指标及母婴结局的影响。方法将88例早发型重度子痫前期患者根据治疗方式分为对照组与观察组,各44例。对照组给予硫酸镁治疗,观察组在对照组基础上给予小剂量低分子肝素钙治疗。比较两组的临床效果。结果治疗后,两组的SBP、DBP、MAP水平均降低,RI、PI、TAV、S/D均改善,PT、APTT均延长,DD、FIB水平均降低,且观察组优于对照组(P<0.05)。观察组的胎盘早剥和HELLP综合征发生率低于对照组(P<0.05)。结论小剂量低分子肝素钙治疗早发型重度子痫前期患者效果明显,能有效降低血压,改善胎盘血流动力学指标和母婴结局。Objective To analyze the effect of low-dose of low molecular weight heparin calcium on placental hemodynamic indexes and maternal and infant outcomes in patients with early onset severe preeclampsia.Methods A total of 88 patients with early onset severe preeclampsia were divided into control group and observation group by the treatment method,with 44 cases in each group.The control group was treated with magnesium sulfate,and the observation group was given low-dose of low molecular weight heparin calcium on the basis of the control group.The clinical effects of the two groups were compared.Results After treatment,the SBP,DBP,MAP levels in the two groups decreased,the RI,PI,TAV and S/D improved,the PT and APTT prolonged,DD and FIB levels decreased,and those in the observation group were better than the control group(P<0.05).The incidence of placental abruption and HELLP syndrome in the observation group were lower than those in the control group(P<0.05).Conclusion Low-dose of low molecular weight heparin calcium in the treatment of patients with early onset severe preeclampsia has obvious effect,which can effectively reduce blood pressure,improve placental hemodynamic indexes and maternal and infant outcomes.

关 键 词：低分子肝素钙 早发型重度子痫前期 血流动力学 

分 类 号：R714.244[医药卫生—妇产科学]