正五聚蛋白3在多囊卵巢综合征中的作用研究进展  

Research progress on the role of pentraxin 3 in polycystic ovary syndrome

作　　者：吴唯 徐键[1,2] WU Wei;XU Jian(Department of Reproductive Endocrinology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Department of Gynecology and Obstetrics,the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属妇产科医院生殖内分泌科,浙江杭州310006 [2]浙江大学医学院附属第四医院妇产科,浙江义乌322000

出　　处：《浙江大学学报（医学版）》2020年第5期637-643,共7页Journal of Zhejiang University(Medical Sciences)

基　　金：国家重点研发计划(2019YFC0121000)。

摘　　要：多囊卵巢综合征(PCOS)是育龄妇女常见的内分泌疾病,是女性不孕的主要原因之一。正五聚蛋白3(PTX3)是一类多功能蛋白质,具有一系列生物活性作用。PTX3参与调节胰岛素分泌及葡萄糖代谢、卵巢卵丘细胞功能、炎症因子活动、雄激素代谢、脂质吸收转运、内皮细胞功能,进而发挥改善胰岛素抵抗、促进卵泡发育与排卵、减弱慢性炎症反应、抑制雄激素水平、改善脂代谢异常和预防动脉粥样硬化及心血管疾病等作用,参与PCOS及其并发症的发生。本文就PTX3在PCOS及其并发症中的作用机制进行综述,以期为PCOS发病机制的深入研究及临床诊疗提供新的思路与方向。Polycystic ovary syndrome(PCOS)is a common endocrine disease of child-bearing period women and one of the main causes of infertility in women.Pentraxin 3(PTX3)is a multifunctional protein with a series of biological activities.PTX3 participates in the regulation of insulin secretion and glucose metabolism,ovarian cumulus cell function,inflammatory factor activity,androgen metabolism,lipid absorption and transport,and endothelial cell function,thereby improving insulin resistance,promoting follicular development and ovulation,reducing chronic inflammation,inhibiting androgen levels,improving lipid metabolism abnormalities and preventing atherosclerosis and cardiovascular diseases,thus participating in the occurrence of PCOS and its complications.This article reviews the mechanism of PTX3 in PCOS and its complications,trying to provide new ideas and directions for the study of PCOS pathogenesis and its clinical diagnosis and treatment.

关 键 词：正五聚蛋白3 多囊卵巢综合征 胰岛素抵抗 卵泡发育 炎症反应 脂代谢 雄激素 综述 

分 类 号：R711.75[医药卫生—妇产科学]