拉莫三嗪片致重症多形性红斑1例分析  

One Case of Lamotrigine-induced Severe Erythema Multiforme Drug Eruption

作　　者：王晓[1] 吴玲娣 王军 魏伟 王维波 王海英 WANG Xiao;WU Lingdi;WANG Jun;WEI Wei;WANG Weibo;WANG Haiying(Sheng li Oilfield Central Hospital,Dongying Shandong 257034,China;Shandong Center for Food and Drug Evaluation&Certification,Jinan Shandong 250041,China;Inspection Center for Food and Drug,Dongying Shandong 257091,China;Dongying People's Hospital,Dongying Shandong 257091,China)

机构地区：[1]胜利油田中心医院,山东东营257034 [2]山东省食品药品审评认证中心,山东济南250041 [3]东营市食品药品检验中心,山东东营257091 [4]东营市人民医院,山东东营257091

出　　处：《中国药物警戒》2020年第11期835-837,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨拉莫三嗪致重症多形性红斑的处置措施。方法分析1例拉莫三嗪致重症多形性红斑的诊疗经过,结合文献检索,探讨拉莫三嗪致重症多形性红斑的机制和应对措施。结果患者服用拉莫三嗪第55天诊断为重症多形性红斑,立即停用并静脉滴注甲泼尼龙琥珀酸钠等相关治疗,患者病情逐步好转。停药第19天,患者皮疹明显好转,瘙痒感消失。结论拉莫三嗪致重症多形性红斑应立即停药,给予糖皮质激素等对症治疗。Objective To explore ways to treat Stevens Johnson syndrome induced by lamotrigine.Methods The diagnosis and treatment of one case of Stevens Johnson syndrome induced by lamotrigine was analyzed.The mechanism by which lamotrigine induced Stevens Johnson syndrome was discussed in combination with literature.Results The patient was diagnosed with Stevens Johnson syndrome on the 55th day he took lamotrigine.The drug was stopped immediately.His condition gradually improved after the treatment with intravenous methylprednisolone sodium succinate.Skin rash was significantly improved,and itching disappeared on the 19th day of withdrawal.Conclusion The use of lamotrigine should be stopped immediately should Stevens Johnson syndrome occur.Glucocorticoid and other drugs should be given as symptomatic treatment.

关 键 词：拉莫三嗪 重症多形性红斑 不良反应 

分 类 号：R994.11[医药卫生—毒理学]