肥胖因子三丁基锡影响细胞代谢功能的研究进展  

Research Progress on the Effect of Tributyltin on Cell Metabolism

作　　者：赵啸宇 朱琼 恽朝晖 王晓蓉 季林丹[3,4] 徐进 ZHAO Xiaoyu;ZHU Qiong;YUN Zhaohui;WANG Xiaorong;JI Lindan;XU Jin(Department of Preventive Medicine,Medical School of Ningbo University,Ningbo 315211,China;Department of Pediatrics,Yinzhou Hospital,Medical School of Ningbo University,Ningbo 315040,China;Department of Biochemistry and Molecular Biology,Medical School of Ningbo University,Ningbo 315211,China;Zhejiang Key Laboratory of Pathophysiology,Medical School of Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学院预防医学系,宁波315211 [2]宁波大学医学院附属鄞州医院,宁波315040 [3]宁波大学医学院生物化学与分子生物学系,宁波315211 [4]浙江省病理生理学技术研究重点实验室,宁波315211

出　　处：《中国细胞生物学学报》2020年第9期1650-1655,共6页Chinese Journal of Cell Biology

基　　金：浙江省公益技术应用研究项目(批准号:2017C33151、LGF20H260009);浙江省医药卫生科技计划(批准号:2019KY648)资助的课题。

摘　　要：肥胖是诸多心、脑血管疾病和代谢性疾病的危险因素。近年来随着全球肥胖人数的快速增加,肥胖现已成为重要的公共卫生问题之一。肥胖除了与遗传、能量摄入过量、缺乏运动等因素有关外,许多环境内分泌干扰物在肥胖发生的过程中也起了重要的作用。在诸多的内分泌干扰物中,三丁基锡是最早被认定为属于肥胖因子(obesogen)范畴的一种化合物,它能够通过促进脂肪堆积、干扰激素分泌等途径导致肥胖的发生。该文对三丁基锡干扰细胞代谢,促进肥胖发生的主要方式及机制进行综述。Obesity is a risk factor for many cardiovascular,cerebrovascular,and metabolic diseases.With the rapid increase of obesity in recent years it has been one of the critical public health issues in the world.In addition to genetic factors,excessive energy intake,lack of exercise and other factors,many environmental endocrine disruptors may also play important roles in obesity.Among these environmental endocrine disruptors,tributyltin is one of the earliest known compounds belonging to the category of obesogen,since it can cause obesity by promoting fat accumulation and interfering with hormone secretion.This review summarizes the recent studies on the mechanisms of tributyltin interferes with cellular metabolism and promotes obesity.

关 键 词：三丁基锡 内分泌干扰物 代谢异常 肥胖 

分 类 号：R589.2[医药卫生—内分泌]